Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene
therapeutic compounds which hold enormous clinical potential. Despite their undoubted …

Advances in solid drug nanoparticle technologies have resulted in a number of long-acting
(LA) formulations with the potential for once monthly or longer administration. Such …

Nanoparticles (NPs) are widely used as components of drugs or cosmetics and hold great
promise for biomedicine, yet their effects on cell physiology remain poorly understood. Here …

Oral delivery of biopharmaceuticals, for example peptides and proteins, constitutes a great
challenge in drug delivery due to their low chemical stability and poor permeation across the …

Non-injectable delivery of peptide and protein drugs is hampered by their labile nature,
hydrophilicity, and large molecular size; thus limiting their permeation across mucosae …

The potential therapeutic and diagnostic applications of oligonucleotides (ONs) have
attracted great attention in recent years. The capability of ONs to selectively inhibit target …

The majority of nanoparticles designed for cellular delivery of drugs and imaging agents
enter the cell via endocytotic pathways leading to their entrapment in endosomes that …

Cell penetrating peptide (CPP) technologies provide a viable strategy to regulate the
activities of intracellular proteins that may be intractable to other biological agents. In …

To electrochemically sense lymphoma cells (U937), we fabricated a multifunctional peptide
probe that consists of cell-penetrating/apoptosis-inducing/electron-transfer peptides …

Cells as the smallest unit of life rely on precise macromolecules and programmable
supramolecular interactions to accomplish the various vital functions. To translate such …