Oncogenic Notch signaling in T-cell and B-cell lymphoprolife... : Current Opinion in Hematology
Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders : Current Opinion …

Genetic mutations of oncogenes often underlie deranged cell growth and altered
differentiation pathways leading to malignant transformation of B-lymphocytes. However …

Abstract WD repeat domain 5 (WDR5) plays an important role in various biological functions
through the epigenetic regulation of gene transcription. However, the oncogenic effect of …

Impaired function of the Ikaros (IKZF1) protein is associated with the development of high-
risk B-cell precursor acute lymphoblastic leukemia (B-ALL). The mechanisms of Ikaros tumor …

IKZF1 (Ikaros) encodes a DNA-binding protein that acts as a master regulatory of
hematopoiesis and a tumor suppressor in acute lymphoblastic leukemia (ALL). 1-4 The …

Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal
rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to …

Acute lymphoblastic leukemia (ALL) remains the leading cause of cancer-related death in
children and young adults. Compared to ALL in children, adult ALL has a much lower cure …

Thymic stromal lymphopoietin (TSLP) stimulates in vitro proliferation of human fetal B-cell
precursors. However, its in vivo role during normal human B lymphopoiesis is unknown …

Abstract Dynamin-2 (DNM2) is a GTPase essential for intracellular vesicle formation and
trafficking, cytokinesis and receptor endocytosis. Mutations in DNM2 are common in early T …

Abstract Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development
and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated …