Extracellular vesicle isolation and characterization: toward clinical application

R Xu, DW Greening, HJ Zhu… - The Journal of …, 2016 - Am Soc Clin Investig
Two broad categories of extracellular vesicles (EVs), exosomes and shed microvesicles
(sMVs), which differ in size distribution as well as protein and RNA profiles, have been …

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

JM Pitt, G Kroemer, L Zitvogel - The Journal of clinical …, 2016 - Am Soc Clin Investig
Intercellular signaling via extracellular vesicles (EVs) is an underappreciated modality of cell-
cell crosstalk that enables cells to convey packages of complex instructions to specific …

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

RA Haraszti, MC Didiot, E Sapp, J Leszyk… - Journal of …, 2016 - Taylor & Francis
Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), are explored for
use in diagnostics, therapeutics and drug delivery. However, little is known about the …

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

Y Qin, L Wang, Z Gao, G Chen, C Zhang - Scientific reports, 2016 - nature.com
Emerging evidence suggests that extracellular vesicles (EVs) are secreted by diverse
tissues and play important roles in cell-cell communication, organ interactions and tissue …

Extracellular vesicles in neurodegenerative disease—pathogenesis to biomarkers

AG Thompson, E Gray, SM Heman-Ackah… - Nature Reviews …, 2016 - nature.com
To develop effective disease-modifying therapies for neurodegenerative diseases, reliable
markers of diagnosis, disease activity and progression are a research priority. The fact that …

Microvesicles and exosomes: new players in metabolic and cardiovascular disease

C Lawson, JM Vicencio, DM Yellon… - Journal of …, 2016 - joe.bioscientifica.com
The past decade has witnessed an exponential increase in the number of publications
referring to extracellular vesicles (EVs). For many years considered to be extracellular …

The biodistribution and immune suppressive effects of breast cancer–derived exosomes

SW Wen, J Sceneay, LG Lima, CSF Wong, M Becker… - Cancer research, 2016 - AACR
Small membranous secretions from tumor cells, termed exosomes, contribute significantly to
intercellular communication and subsequent reprogramming of the tumor microenvironment …

A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

Z Zhao, Y Yang, Y Zeng, M He - Lab on a Chip, 2016 - pubs.rsc.org
Tumor-derived circulating exosomes, enriched with a group of tumor antigens, have been
recognized as a promising biomarker source for cancer diagnosis via a less invasive …

Effective isolation of exosomes with polyethylene glycol from cell culture supernatant for in-depth proteome profiling

Y Weng, Z Sui, Y Shan, Y Hu, Y Chen, L Zhang… - Analyst, 2016 - pubs.rsc.org
Exosomes are secreted nanovesicles shed by almost all kinds of cells. Recently, increased
interest has been focused on these extracellular vesicles as natural carriers transporting …

[HTML][HTML] Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer

X Meng, V Müller, K Milde-Langosch, F Trillsch… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Exosomes are membrane vesicles that mediate intercellular communication by transporting
their molecular cargo from cell to cell. We investigated whether serum levels of exosomal …