Hypoxia is a potent microenvironmental factor that promotes tumor metastasis. Recent
studies have revealed mechanisms by which hypoxia and activation of hypoxia inducible …

Summary Following HIV/AIDS, tuberculosis (TB) continues to be the second most deadly
infectious disease in humans. The global TB prevalence has become worse in recent years …

The local immune response is important to consider when the aim is to improve bone
regeneration. Recently T lymphocytes and their associated cytokines have been identified …

CD8+ cytotoxic T lymphocytes (CTLs) are critical for clearing many viral infections, and
protective CTL memory can be induced by vaccination with attenuated viruses and vectors …

Despite decades of research, malaria remains a global health crisis. Current subunit vaccine
approaches do not provide efficient long-term, sterilizing immunity against Plasmodium …

High epitope‐specific sensitivity of CD8+ T cells is required for optimal immune protection
against intracellular pathogens as well as certain malignancies. The quality of antigen …

Exercise immunology research has traditionally focussed on aerobic-exercise, however it
has become apparent in more recent years that resistance-exercise can also considerably …

Poor maintenance of cytotoxic factor expression among HIV-specific CD8+ T cells, in part
caused by dysregulated expression of the transcription factor T-bet, is associated with HIV …

The p110δ isoform of PI3K is known to play an important role in immunity, yet its contribution
to CTL responses has not been fully elucidated. Using murine p110δ-deficient CD8+ T cells …

Recent findings have revealed roles for systemic and mucosa-resident memory CD8+ T
cells in the orchestration of innate immune responses critical to host defense upon microbial …