Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte
populations show an increase in number and function after antigen encounter and more …

T cells have a pivotal protective role in defense against infection and cancer but also are
instrumental in the development of many autoimmune diseases. The regulation of nutrient …

Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass
spectrometry, we generated dynamic metabolome and proteome profiles of human primary …

Dynamic reprogramming of metabolism is essential for T cell effector function and memory
formation. However, the regulation of metabolism in exhausted CD8+ T (Tex) cells is poorly …

R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function
isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2 …

Long-term survival and antitumor immunity of adoptively transferred CD8+ T cells is
dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on …

Primary immunodeficiencies are inherited disorders of the immune system, often caused by
the mutation of genes required for lymphocyte development and activation. Recently …

Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …

Asymmetric cell division, the partitioning of cellular components in response to polarizing
cues during mitosis, has roles in differentiation and development. It is important for the self …

The PI3K pathway is hyperactivated in most cancers, yet the capacity of PI3K inhibitors to
induce tumor cell death is limited. The efficacy of PI3K inhibition can also derive from …