Exosomal miRNAs as cancer biomarkers and therapeutic targets
A Thind, C Wilson - Journal of extracellular vesicles, 2016 - Taylor & Francis
Intercommunication between cancer cells and with their surrounding and distant
environments is key to the survival, progression and metastasis of the tumour. Exosomes …
environments is key to the survival, progression and metastasis of the tumour. Exosomes …
The role of microRNAs in the pathogenesis of autoimmune diseases
MicroRNAs (miRNAs) are single-stranded, endogenous non-coding small RNAs, ranging
from 18 to 25 nucleotides in length. Growing evidence suggests that miRNAs are essential …
from 18 to 25 nucleotides in length. Growing evidence suggests that miRNAs are essential …
[HTML][HTML] Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis
K Bogunia-Kubik, B Wysoczańska, D Piątek… - Archivum immunologiae …, 2016 - Springer
Abstract MicroRNA-146a (miR-146a) has been shown to play an important role in the
regulation of inflammatory innate immune responses, and found to be differentially …
regulation of inflammatory innate immune responses, and found to be differentially …
[HTML][HTML] Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients
J Ogando, M Tardáguila, A Díaz-Alderete, A Usategui… - Scientific reports, 2016 - nature.com
Evidence links aryl hydrocarbon receptor (AHR) activation to rheumatoid arthritis (RA)
pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory …
pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory …
Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression
C Angiolilli, AM Grabiec, BS Ferguson… - Annals of the …, 2016 - ard.bmj.com
Objectives Epigenetic modifications play an important role in the regulation of gene
transcription and cellular function. Here, we examined if pro-inflammatory factors present in …
transcription and cellular function. Here, we examined if pro-inflammatory factors present in …
Prediction of treatment response to adalimumab: a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis
SB Krintel, C Dehlendorff, ML Hetland… - The …, 2016 - nature.com
At least 30% of patients with rheumatoid arthritis (RA) do not respond to biologic agents,
which emphasizes the need of predictive biomarkers. We aimed to identify microRNAs …
which emphasizes the need of predictive biomarkers. We aimed to identify microRNAs …
[HTML][HTML] X-linked miRNAs associated with gender differences in rheumatoid arthritis
O Khalifa, YM Pers, R Ferreira, A Sénéchal… - International journal of …, 2016 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease that predominantly affects women.
MicroRNAs have emerged as crucial regulators of the immune system, whose expression is …
MicroRNAs have emerged as crucial regulators of the immune system, whose expression is …
[HTML][HTML] MicroRNA-125b: association with disease activity and the treatment response of patients with early rheumatoid arthritis
V Hruskova, R Jandova, L Vernerova, H Mann… - Arthritis research & …, 2016 - Springer
Background MicroRNAs (miRNAs) are small RNAs that regulate gene expression by
targeting mRNA. It was proved that some miRNAs are significantly deregulated in …
targeting mRNA. It was proved that some miRNAs are significantly deregulated in …
Expression of miR-146a, miR-155, and miR-223 in formalin-fixed paraffin-embedded synovial tissues of patients with rheumatoid arthritis and osteoarthritis
M Kriegsmann, TM Randau, S Gravius, K Lisenko… - Virchows Archiv, 2016 - Springer
Rheumatoid arthritis (RA) is a chronic autoimmune disease with a heterogeneous clinical
presentation affecting about 1% of adults in developed countries. Currently, the diagnosis is …
presentation affecting about 1% of adults in developed countries. Currently, the diagnosis is …
LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p
YY Wang, ZY Wu, GC Wang, K Liu, XB Niu, S Gu… - Tumor Biology, 2016 - Springer
To investigate the influence of the long non-coding RNA LINC00312 on bladder cancer (BC)
cell invasion and metastasis by targeting miR-197-3p. BC and corresponding adjacent …
cell invasion and metastasis by targeting miR-197-3p. BC and corresponding adjacent …