Sepsis and septic shock

RS Hotchkiss, LL Moldawer, SM Opal… - Nature reviews Disease …, 2016 - nature.com
For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

PASylated coversin, a C5-specific complement inhibitor with extended pharmacokinetics, shows enhanced anti-hemolytic activity in vitro

N Kuhn, CQ Schmidt, M Schlapschy… - Bioconjugate …, 2016 - ACS Publications
The Ornithodoros moubata Complement Inhibitor (OmCI) binds complement component 5
(C5) with high affinity and, thus, selectively prevents proteolytic activation of the terminal lytic …

Inhibition of phosphodiesterase-4 during pneumococcal pneumonia reduces inflammation and lung injury in mice

LP Tavares, CC Garcia, JP Vago… - American journal of …, 2016 - atsjournals.org
Pneumococcal pneumonia is a leading cause of mortality worldwide. The inflammatory
response to bacteria is necessary to control infection, but it may also contribute to tissue …

PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice

J Hu, Y Mo, Z Gao, X Wang, M Gu, Y Liang… - Medical microbiology …, 2016 - Springer
PA-X is a novel discovered accessory protein encoded by the PA mRNA. Our previous study
demonstrated that PA-X decreases the virulence of a highly pathogenic H5N1 strain …

Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation

M Osaka, S Ito, M Honda, Y Inomata, K Egashira… - Scientific reports, 2016 - nature.com
Exceed and chronic high-fat diet (HFD) contributes to the diagnosis and development of
atherosclerosis, obesity and metabolic syndrome. However, the key molecular component …

Identification of differentially expressed transcripts targeted by the knockdown of endogenous IFITM3

C Shen, YJ Li, QQ Yin, WW Jiao… - Molecular …, 2016 - spandidos-publications.com
Interferon inducible transmembrane protein 3 (IFITM3) is a double transmembrane protein.
As a member of the IFITM family, IFITM3 can be upregulated by interferon (IFN) to be …

Porcine endothelium induces DNA–histone complex formation in human whole blood: a harmful effect of histone on coagulation and endothelial activation

HJ Yoo, JE Kim, JY Gu, SB Lee, HJ Lee… - …, 2016 - Wiley Online Library
Background Neutrophils play a role in xenograft rejection. When neutrophils are stimulated,
they eject the DNA–histone complex into the extracellular space, called neutrophil …

Opportunities for the development of novel therapies based on host-microbial interactions

PC Santos, MM Teixeira, DG Souza - Pharmacological Research, 2016 - Elsevier
Immune responses are fundamental for protecting against most infectious agents. However,
there is now much evidence to suggest that the pathogenesis and tissue damage after …

Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis

TE Faber, TA Schuurs, NJGM Veeger… - Pediatric …, 2016 - Wiley Online Library
The effect of viral infection on nasopharyngeal carriage of Streptococcus pneumoniae
during childhood is not well known. We studied dynamics of pneumococcal colonization by …

[PDF][PDF] The role of ADAMTS enzymes in influenza virus immunity

M McMahon - 2016 - dro.deakin.edu.au
The role of ADAMTS enzymes in influenza virus immunity Page 1 The role of ADAMTS
enzymes in influenza virus immunity AUTHOR(S) M McMahon PUBLICATION DATE 01-11-2016 …