Safety of secukinumab in the treatment of psoriasis

A Blauvelt - Expert opinion on drug safety, 2016 - Taylor & Francis
Introduction: Secukinumab is a human monoclonal antibody that selectively targets and
neutralizes interleukin (IL)-17A, a cytokine that is normally involved in mucocutaneous …

A review of biologic therapies targeting IL-23 and IL-17 for use in moderate-to-severe plaque psoriasis

M Campa, B Mansouri, R Warren, A Menter - Dermatology and therapy, 2016 - Springer
The development of several highly effective biologic drugs in the past decade has
revolutionized the treatment of moderate-to-severe plaque psoriasis. With increased …

Secukinumab long-term safety experience: a pooled analysis of 10 phase II and III clinical studies in patients with moderate to severe plaque psoriasis

PCM van de Kerkhof, CEM Griffiths, K Reich… - Journal of the American …, 2016 - Elsevier
Background Secukinumab, a fully human anti–interleukin-17A monoclonal antibody, has
demonstrated efficacy and safety in patients with moderate to severe plaque psoriasis …

Secukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low …

A Karle, S Spindeldreher, F Kolbinger - MAbs, 2016 - Taylor & Francis
Secukinumab is a human monoclonal antibody that selectively targets interleukin-17A and
has been demonstrated to be highly efficacious in the treatment of moderate to severe …

Anti-IL-17 medications used in the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review

TN Canavan, CA Elmets, WL Cantrell, JM Evans… - American journal of …, 2016 - Springer
Our ability to successfully treat patients with moderate to severe psoriasis has improved
significantly over the last several years with the development of more targeted therapies. IL …

Стратегия" лечение до достижения цели" при псориазе. Актуальные вопросы устойчивости к биологической терапии

АЛ Бакулев - Вестник дерматологии и венерологии, 2016 - elibrary.ru
В обзоре обсуждается возможность применения терапевтической стратегии «лечение
до достижения цели»(Т2Т) при псориазе, а также анализируются ключевые факторы …

The role of IL-17 in the pathogenesis of psoriasis and update on IL-17 inhibitors for the treatment of plaque psoriasis

M AbuHilal, S Walsh, N Shear - Journal of cutaneous …, 2016 - journals.sagepub.com
Background: Major advances have been made in the understanding of the pathophysiology
of psoriasis. Objectives: The authors review the role of interleukin (IL) 17 in the pathogenesis …

Meta-analysis of the efficacy and safety of secukinumab for the treatment of plaque psoriasis

JY Ryoo, HJ Yang, E Ji, BK Yoo - Annals of …, 2016 - journals.sagepub.com
Background: In January 2015, US FDA approved secukinumab, a human interleukin-17A (IL-
17A) antagonist, for the treatment of plaque psoriasis. Objective: To provide unbiased drug …

Novel systemic therapies for the treatment of psoriasis

KW Tan, CEM Griffiths - Expert opinion on pharmacotherapy, 2016 - Taylor & Francis
Introduction: The immunopathogenesis of psoriasis has led to the discovery and
development of several promising treatment options for psoriasis, including those that target …

Small molecules and antibodies for the treatment of psoriasis: a patent review (2010–2015)

A Chiricozzi, R Saraceno, L Novelli, M Fida… - Expert Opinion on …, 2016 - Taylor & Francis
Introduction: Psoriasis is a chronic condition whose therapeutic armamentarium is
increasingly being discussed, particularly when compared to past decades. The use of …