Acute lymphoblastic leukemia (ALL) is a heterogeneous disease at the genetic level.
Chromosomal abnormalities are used as diagnostic, prognostic and predictive biomarkers to …

While the majority of children and adolescents with newly diagnosed childhood acute
lymphoblastic leukemia (ALL) will be cured, as many as 20% of patients will experience …

Successful Therapy Reduction and Intensification for Childhood Acute Lymphoblastic Leukemia
Based on Minimal Residual Disease Mo Page 1 JOURNAL OF CLINICAL ONCOLOGY …

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion
gene landscape in a consecutive series of 195 paediatric B-cell precursor acute …

The clinical success of the BCL-2-selective BH3-mimetic venetoclax in patients with poor
prognosis chronic lymphocytic leukemia (CLL) highlights the potential of targeting the BCL-2 …

Deletions in IKZF1 are found in~ 15% of children with B-cell precursor acute lymphoblastic
leukemia (BCP-ALL). There is strong evidence for the poor prognosis of IKZF1 deletions …

Recent studies revealed that a substantial proportion of patients with high-risk B-cell
precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase …

To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias,
representing targetable kinase-activating lesions, we analyzed 44 new and published cases …

Background ZNF384 gene rearrangements with multiple partner genes are recurrent in
acute leukemia and are most often associated with a precursor B cell immunophenotype …

Acute lymphoblastic leukemia (ALL) remains an important cause of morbidity in children and
adults. In this article, we highlight advances in the genetics and therapy of three key …