Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …

Prostate cancer is one of the most common non-cutaneous malignancies among men
worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or …

Histone deacetylase (HDAC) 6 is a unique isoenzyme targeting specific substrates including
α-tubulin and heat shock protein (HSP) 90. HDAC6 is involved in protein trafficking and …

Despite recent advances in the treatment of advanced prostate cancer (PCa), metastatic
castrate-resistant PCa remains incurable at this time. The androgen receptor (AR) plays a …

Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as
anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay …

The active form of the Drosophila steroid hormone ecdysone, 20-hydroxyecdysone (20E),
binds the heterodimer EcR/USP nuclear receptor to regulate target genes that elicit …

We determined whether prostate specific antigen (PSA) would decrease with immediate
antiandrogen switching from bicalutamide (BCL) to flutamide (FLT) in patients receiving …

Background The androgen receptor (AR) can be stimulated by interleukin-6 (IL-6) in the
absence of androgens to induce prostate cancer progression. The purpose of this study was …

Background Recommendations for cancer screening are uncertain for the early detection or
prevention of prostate cancer in African American men. Thus, chemoprevention strategies …

Y-box binding protein 1 (YB-1) is an imperative biomarker for the clinical outcome of cancer
patients. An overexpression of YB-1 in cancerous and adjoining tissues is an indication of …