Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to …

Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose
tissue. This protein acts on the hypothalamic regions of the brain which control eating …

The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However,
who becomes obese in an obesity-prone environment is largely determined by genetic …

Conclusions: Modest weight gain in healthy individuals is associated with increases in
adiponectin levels, which correlate positively with changes in leptin. In vitro, leptin induces …

Since the discovery of leptin as an adipokine in 1994, much progress has been made in the
research about leptin. Circulating leptin binds to leptin receptor, activates STAT3-dependent …

It will not be surprising to most people how ubiquitous obesity is today, both in America and
throughout the world. Nor should it be surprising how frequently male hypogonadism is …

Obesity is rising to unprecedented numbers, affecting a growing number of children,
adolescents and young adult men. These individuals face innumerous health problems …

Objective Recombinant human leptin (metreleptin) improves glycaemia and
hypertriglyceridaemia in patients with generalized lipodystrophy; antibody development with …

Understanding the numerous factors involved with body weight regulation and identifying
interventions to prevent or treat the problem is an enormous task in and of itself. Addressing …