Eosinophils are a minority circulating granulocyte classically viewed as being involved in
host defense against parasites and promoting allergic reactions. However, a series of new …

Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly
with traditional risk factors precipitates their manifestation. Whereas the implications of a …

Background In patients with severe eosinophilic asthma, local maturation rather than
systemic recruitment of mature cells might contribute to persistent airway eosinophilia …

An exciting new era has dawned for the prevention and management of coronary artery
disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …

Eosinophils have traditionally been associated with allergic diseases and parasite infection.
Research advances in the recent decades have brought evolutionary changes in our …

Asthma is a global health problem with increasing prevalence. The airway epithelium is the
initial barrier against inhaled noxious agents or aeroallergens. In asthma, the airway …

IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past
several decades have markedly expanded our understanding of its cellular sources and …

Platelet production, maintenance, and clearance are tightly controlled processes indicative
of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for …

Coronary artery disease (CAD) including myocardial infarction (MI) is a common disease
and among the leading cause of death in the world. The onset of CAD depends on complex …

Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes
mellitus type 1, and hypertension in genome-wide association studies, whereas mouse …