Building nanostructures with drugs

W Ma, AG Cheetham, H Cui - Nano today, 2016 - Elsevier
The convergence of nanoscience and drug delivery has prompted the formation of the field
of nanomedicine, one that exploits the novel physicochemical and biological properties of …

Anticancer nanoparticulate polymer‐drug conjugate

Q Feng, R Tong - Bioengineering & translational medicine, 2016 - Wiley Online Library
We review recent progress in polymer‐drug conjugate for cancer nanomedicine. Polymer‐
drug conjugates, including the nanoparticle prepared from these conjugates, are designed …

Doxorubicin-loaded biodegradable self-assembly zein nanoparticle and its anti-cancer effect: Preparation, in vitro evaluation, and cellular uptake

F Dong, X Dong, L Zhou, H Xiao, PY Ho… - Colloids and Surfaces B …, 2016 - Elsevier
Cancer is one top leading cause of the deaths worldwide. Various anticancer drugs, which
can effectively kill cancer cells, have been developed in the last decade. However, the …

A small molecule nanodrug consisting of amphiphilic targeting ligand–chemotherapy drug conjugate for targeted cancer therapy

Q Mou, Y Ma, X Zhu, D Yan - Journal of Controlled Release, 2016 - Elsevier
Targeted drug delivery is a broadly applicable approach for cancer therapy. However, the
nanocarrier-based targeted delivery system suffers from batch-to-batch variation, quality …

Supramolecular vesicles based on complex of trp-modified pillar [5] arene and galactose derivative for synergistic and targeted drug delivery

K Yang, Y Chang, J Wen, Y Lu, Y Pei, S Cao… - Chemistry of …, 2016 - ACS Publications
Failure of cancer treatment is mainly caused by adverse side effects to normal cells and
multidrug resistance (MDR) of cancer cells induced by chemotherapy. 1, 2 Targeting and …

Traceable nanoparticle delivery of small interfering RNA and retinoic acid with temporally release ability to control neural stem cell differentiation for Alzheimer's …

R Zhang, Y Li, B Hu, Z Lu, J Zhang… - Advanced …, 2016 - Wiley Online Library
DOI: 10.1002/adma. 201600554 application of NSCs would be based on controlled
differentiation of NSCs to neurons and long-term monitoring in real time. For the aspect of …

Facile construction of pH-and redox-responsive micelles from a biodegradable poly (β-hydroxyl amine) for drug delivery

D Li, Y Bu, L Zhang, X Wang, Y Yang… - …, 2016 - ACS Publications
Here we demonstrate a type of pH and reduction dual-sensitive biodegradable micelles,
which were self-assembled by a cationic polymer in an aqueous solution. Due to tumor cells …

Self-assembled targeted nanoparticles based on transferrin-modified eight-arm-polyethylene glycol–dihydroartemisinin conjugate

K Liu, L Dai, C Li, J Liu, L Wang, J Lei - Scientific Reports, 2016 - nature.com
Poor delivery of insoluble anticancer drugs has so far precluded their clinical application. In
this study, an efficient tumor targeted-nanoparticle delivery system, transferrin-eight-arm …

Self-delivery of a peptide-based prodrug for tumor-targeting therapy

M Peng, S Qin, H Jia, D Zheng, L Rong, X Zhang - Nano Research, 2016 - Springer
A novel self-delivered prodrug system was fabricated for tumor-targeting therapy. In this
nanosystem, the Arg-Gly-Asp-Ser (RGDS) tetrapeptide was used to improve the therapeutic …

One-step “click chemistry”-synthesized cross-linked prodrug nanogel for highly selective intracellular drug delivery and upregulated antitumor efficacy

Y Zhang, J Ding, M Li, X Chen, C Xiao… - … applied materials & …, 2016 - ACS Publications
Polymeric prodrugs formed by the conjugation of drugs onto polymers have shown great
promise in cancer therapy because of the enhancement of water solubility, elimination of …