Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Skeletal muscle-specific stem cells are pivotal for tissue development and regeneration.
Muscle plasticity, inherent in these processes, is also essential for daily life activities. Great …

Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by genetic
mutations that lead to the disruption of dystrophin in muscle fibers. There is no curative …

Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy,
exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism …

Muscle uses Ca 2+ as a messenger to control contraction and relies on ATP to maintain the
intracellular Ca 2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP …

Muscle is a soft tissue, whose main purpose is to produce motion and force in animals. The
generation of limb and trunk movements, the control of breathing as well as involuntary …

Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by mutations in
the dystrophin gene. DMD is clinically characterized by severe, progressive and irreversible …

The purpose of this study was to examine the effects of increased extracellular leucine
concentration on protein metabolism in skeletal muscle cells when exposed to 3 different …

The present invention provides methods for improving mus cular function or treating a
muscular disorder in an indi vidual by administering to the individual a pharmacologi cally …