Compaction of DNA into chromatin is a characteristic feature of eukaryotic organisms. The
core (H2A, H2B, H3, H4) and linker (H1) histone proteins are responsible for this compaction …

The nucleosome is the fundamental unit for packaging the genome. A detailed molecular
picture for its conformational dynamics is crucial for understanding transcription and gene …

Nucleosome breathing potentially increases the DNA exposure, which in turn recruits DNA-
binding protein and regulates gene transcription. Numerous studies have shown the critical …

Linker histones are essential for DNA compaction in chromatin. They bind to nucleosomes in
a 1: 1 ratio forming chromatosomes. Alternative configurations have been proposed in which …

Molecular dynamics (MD) simulations based on the implicit solvent generalized Born (GB)
models can provide significant computational advantages over the traditional explicit solvent …

Abstract Effects of local relaxation of the nucleosome structure after DNA unwrapping from
the histone octamer are considered in this paper. The influence of charge distribution in …

Eukaryontische Zellen weisen neben einer hochgradig organisierten Genregulation auch
eine besonders ausgefeilte Kompaktierung der DNA auf, deren Basiseinheit Nukleosomen …

We present here raw trajectories of molecular dynamics simulations for nucleosome with
linker DNA strands as well as minimalistic nucleosome core particle model. The simulations …

Histone post-translational modifications (PTMs) alter chromatin structure by promoting the
interaction of chromatin-modifying complexes with nucleosomes. The majority of chromatin …

В работе рассматриваются эффекты локальной релаксации структуры нуклеосомы
при отворачивании концов ДНК от октамера гистонов. Исследуется влияние …