Liposome based intravesical therapy targeting nerve growth factor ameliorates bladder hypersensitivity in rats with experimental colitis

N Kawamorita, S Yoshikawa, M Kashyap… - The Journal of …, 2016 - auajournals.org
Purpose: Pelvic organ cross sensitization is considered to contribute to overlapping
symptoms in chronic pelvic pain syndrome. Nerve growth factor over expression in the …

Intravesical PAC1 receptor antagonist, PACAP (6–38), reduces urinary bladder frequency and pelvic sensitivity in NGF-OE mice

BM Girard, SE Malley, MM Mathews, V May… - Journal of Molecular …, 2016 - Springer
Chronic NGF overexpression (OE) in the urothelium, achieved through the use of a highly
urothelium-specific uroplakin II promoter, stimulates neuronal sprouting in the urinary …

Effects of cyp-induced cystitis on growth factors and associated receptor expression in micturition pathways in mice with chronic overexpression of ngf in urothelium

BM Girard, S Malley, V May, MA Vizzard - Journal of Molecular …, 2016 - Springer
We have determined if cyclophosphamide (CYP)-induced cystitis produces additional
changes in growth factor/receptors expression in the urinary bladder (urothelium, detrusor) …

Accelerated onset of the vesicovesical reflex in postnatal NGF-OE mice and the role of neuropeptides

B Girard, A Peterson, S Malley, MA Vizzard - Experimental neurology, 2016 - Elsevier
The mechanisms underlying the postnatal maturation of micturition from a somatovesical to
a vesicovesical reflex are not known but may involve neuropeptides in the lower urinary …

Induction of bladder overactivity by nerve growth factor in testes in rats: possible neural crosstalk between the testes and urinary bladder

K Yoshioka, M Tanahashi, M Takeda… - LUTS: Lower Urinary …, 2016 - Wiley Online Library
Objectives To clarify the pathophysiological factor underlying neural crosstalk among pelvic
organs, we investigated the possible role of nerve growth factor (NGF) in the neural crosstalk …

Bexiga neurogênica em crianças e adolescentes: impacto familiar e biomarcadores

TM Dias - 2016 - teses.usp.br
INTRODUÇÃO: Bexiga neurogênica (BN) é um distúrbio da função vesical que pode causar
danos renais irreversíveis. O diagnóstico precoce e o tratamento visam proteger a função …