Targeting DNA mismatches with rhodium metalloinsertors
KM Boyle, JK Barton - Inorganica chimica acta, 2016 - Elsevier
DNA has been exploited as a biological target of chemotherapeutics since the 1940s.
Traditional chemotherapeutics, such as cisplatin and DNA-alkylating agents, rely primarily …
Traditional chemotherapeutics, such as cisplatin and DNA-alkylating agents, rely primarily …
[HTML][HTML] A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy
SC Zimmerman - Beilstein journal of organic chemistry, 2016 - beilstein-journals.org
This review summarizes part of the author's research in the area of supramolecular
chemistry, beginning with his early life influences and early career efforts in molecular …
chemistry, beginning with his early life influences and early career efforts in molecular …
Luminescent platinum (II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA
The selective targeting of mismatched DNA overexpressed in cancer cells is an appealing
strategy in designing cancer diagnosis and therapy protocols. Few luminescent probes that …
strategy in designing cancer diagnosis and therapy protocols. Few luminescent probes that …
Base flipping within the α-hemolysin latch allows single-molecule identification of mismatches in DNA
RP Johnson, AM Fleming, LR Beuth… - Journal of the …, 2016 - ACS Publications
A method for identifying and differentiating DNA duplexes containing the mismatched base
pairs CC and CA at single molecule resolution with the protein pore α-hemolysin (αHL) is …
pairs CC and CA at single molecule resolution with the protein pore α-hemolysin (αHL) is …
Comparative study of affinity and selectivity of ligands targeting abasic and mismatch sites in DNA using a fluorescence-melting assay
N Kotera, A Granzhan, MP Teulade-Fichou - Biochimie, 2016 - Elsevier
Recently, several families of small-molecule ligands have been developed to selectively
target DNA pairing defects, such as abasic sites and mismatched base pairs, with the aim to …
target DNA pairing defects, such as abasic sites and mismatched base pairs, with the aim to …
Cyclic mismatch binding ligand CMBL4 binds to the 5′-T-3′/5′-GG-3′ site by inducing the flipping out of thymine base
S Mukherjee, C Dohno, K Asano… - Nucleic acids …, 2016 - academic.oup.com
A newly designed cyclic bis-naphthyridine carbamate dimer CMBL4 with a limited
conformational flexibility was synthesized and characterized. Absorption spectra revealed …
conformational flexibility was synthesized and characterized. Absorption spectra revealed …
Synthesis of new fused heterocyclic aromatic hydrocarbons via C–S and C–C bond formation by C–H bond activation in the presence of new Pd (ii) Schiff's base …
The Schiff's base aza-macrocyclic Pd (DPTTP) Cl2 and Pd (TPTTP) Cl2 complexes are
efficient photocatalysts for the activation of the C–H bond and the formation of both …
efficient photocatalysts for the activation of the C–H bond and the formation of both …
Zn2+-cyclen-based complex enable a selective detection of single-stranded thymine-rich DNA in aqueous buffer
Z Zhu, S Wang, D Wei, C Yang - Biosensors and Bioelectronics, 2016 - Elsevier
It is a big challenge to develop fluorescent probes for selective detection of DNA with
specific sequences in aqueous buffers. We report a new tetraphenylethene-based Zn 2+ …
specific sequences in aqueous buffers. We report a new tetraphenylethene-based Zn 2+ …
Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids
Y Sato, H Saito, D Aoki, N Teramae… - Chemical …, 2016 - pubs.rsc.org
Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding
affinity to orphan nucleobases in DNA/RNA hybrids - Chemical Communications (RSC …
affinity to orphan nucleobases in DNA/RNA hybrids - Chemical Communications (RSC …
基于碱基错配的核酸分子逻辑运算研究进展
程楠， 徐瑗聪， 许文涛 - 食品工业科技, 2016 - cqvip.com
分子逻辑运算是解决电子计算机发展瓶颈的有效途径, 是实现分子计算机的关键单元.
核酸错配结合Hg2+ 和Ag+ 等重金属离子是功能核酸中非常经典的一类分子基础 …
核酸错配结合Hg2+ 和Ag+ 等重金属离子是功能核酸中非常经典的一类分子基础 …