Diabetic peripheral neuropathy may not be as its name suggests: evidence from magnetic resonance imaging

S Tesfaye, D Selvarajah, R Gandhi, M Greig, P Shillo… - Pain, 2016 - journals.lww.com
Diabetic peripheral neuropathy (DPN) affects up to 50% of patients with diabetes and is a
major cause of morbidity and increased mortality. Its clinical manifestations include …

[HTML][HTML] Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic

JY Zhou, Z Zhang, GS Qian - Cell death discovery, 2016 - nature.com
As one of the most common complications of diabetes, diabetic neuropathy often causes foot
ulcers and even limb amputations. Inspite of continuous development in antidiabetic drugs …

Mesenchymal stem cells as a prospective therapy for the diabetic foot

Q Wu, B Chen, Z Liang - Stem Cells International, 2016 - Wiley Online Library
The diabetic foot is a serious complication of diabetes. Mesenchymal stem cells are an
abundant source of stem cells which occupy a special position in cell therapies, and recent …

The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes

QA Altaf, A Ali, MK Piya, NT Raymond… - Journal of Diabetes and its …, 2016 - Elsevier
Background Obstructive sleep apnea (OSA) is associated with increased nitrosative stress,
endothelial dysfunction, and peripheral neuropathy in patients with type 2 diabetes. We …

Glucotoxic mechanisms and related therapeutic approaches

S Yagihashi - International Review of Neurobiology, 2016 - Elsevier
Neuropathy is the earliest and commonest complication of diabetes. With increasing
duration of diabetes, frequency and severity of neuropathy are worsened. Long-term …

Autophagy: the missing link in diabetic neuropathy?

VG Yerra, C Gundu, P Bachewal, A Kumar - Medical Hypotheses, 2016 - Elsevier
Autophagy is a dynamic process which plays an important role in cellular homeostasis
through recycling of damaged proteins and organelles. Chronic hyperglycemia associated …

Urogenital autonomic dysfunction in diabetes

BH Braffett, H Wessells, AV Sarma - Current Diabetes Reports, 2016 - Springer
This review details the epidemiology, possible mechanisms, and risk factors associated with
urogenital autonomic dysfunction in diabetes. Autonomic neuropathy in diabetes is …

On the characterization of a class of fisher-consistent loss functions and its application to boosting

M Neykov, JS Liu, T Cai - Journal of Machine Learning Research, 2016 - jmlr.org
Accurate classification of categorical outcomes is essential in a wide range of applications.
Due to computational issues with minimizing the empirical 0/1 loss, Fisher consistent losses …

Prediction of protective sensory loss, neuropathy and foot ulceration in type 2 diabetes

RB Paisey, T Darby, AM George, M Waterson… - BMJ Open Diabetes …, 2016 - drc.bmj.com
Objectives To prospectively determine clinical and biochemical characteristics associated
with the development of peripheral neuropathy, loss of protective sensation, and foot …

Making insulin accessible: does inhaled insulin fill an unmet need?

JB McGill, D Ahn, SV Edelman, CR Kilpatrick… - Advances in …, 2016 - Springer
Glycemic control is fundamental to the management of diabetes. However, studies suggest
that a significant proportion of people with diabetes, particularly those using insulin, are not …