Antidepressants have modest efficacy in late-life depression (LLD), perhaps because
various neurobiologic processes compromise frontolimbic networks required for …

Evidence from human studies indicates that maternal metabolic state and malnutrition
dramatically influence the risk for developing psychiatric complications in later adulthood. In …

A novel series of hybrid molecules were designed and synthesized by fusing the
pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as …

Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating
Transforming-Growth-Factor-β1 (TGF-β1) levels in depressed patients, and are currently …

Depressive symptoms are frequently seen in patients with dementia and mild cognitive
impairment (MCI). Evidence suggests that there may be a link between current depressive …

Used as a spice and to improve the palatability of different meat and vegetable dishes,
common fennel, Foeniculum vulgare Mill.(Apiaceae), was a traditional remedy for the relief …

Previous reports suggest that Alzheimer's disease is protected by cholinesterase inhibitors.
We synthesized some isoalloxazine derivatives and evaluated them using in vitro …

This study aimed to determine the effects of different concentrations of soluble beta-amyloid
25–35 (Aβ25–35) on cell viability, calcium overload, and PI3K-p85 expression in cultured …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Neuropathological
hallmarks of AD are amyloid plaques composed of amyloid-β (Aβ), neurofibrillary tangles …

Monomeric forms of soluble amyloid peptides (Aβ40 and Aβ42) arise from proteolytic
cleavage of the amyloid precursor protein through the action of beta and gamma secretases …