Microglia in health and disease
RM Ransohoff, J El Khoury - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Microglia, the major myeloid cells of the central nervous system (CNS) are implicated in
physiologic processes and in the pathogenesis of several CNS disorders. Since their initial …
physiologic processes and in the pathogenesis of several CNS disorders. Since their initial …
Update on inflammatory biomarkers and treatments in ischemic stroke
A Bonaventura, L Liberale, A Vecchié… - International journal of …, 2016 - mdpi.com
After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly
induce both beneficial and detrimental effects. In this narrative review, we updated evidence …
induce both beneficial and detrimental effects. In this narrative review, we updated evidence …
Fractalkine receptor deficiency is associated with early protection but late worsening of outcome following brain trauma in mice
ER Zanier, F Marchesi, F Ortolano, C Perego… - Journal of …, 2016 - liebertpub.com
An impaired ability to regulate microglia activation by fractalkine (CX3CL1) leads to
microglia chronic sub-activation. How this condition affects outcome after acute brain injury …
microglia chronic sub-activation. How this condition affects outcome after acute brain injury …
[HTML][HTML] CX3CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions
W Zhao, H Lu, X Wang, RM Ransohoff… - The FASEB Journal, 2016 - ncbi.nlm.nih.gov
Adequate inflammatory response predominated by macrophage infiltration is essential to
acute skeletal muscle injury repair. The majority of intramuscular macrophages express the …
acute skeletal muscle injury repair. The majority of intramuscular macrophages express the …
Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin
MX Xu, R Yu, LF Shao, YX Zhang, CX Ge… - Brain, Behavior, and …, 2016 - Elsevier
Recent studies suggest that diet-induced fractalkine (FKN) stimulates neuroinflammation in
animal models of obesity, yet how it occurs is unclear. This study investigated the role of …
animal models of obesity, yet how it occurs is unclear. This study investigated the role of …
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes
SA O'Sullivan, F Gasparini, AK Mir, KK Dev - Journal of …, 2016 - Springer
Abstract Background The fractalkine (CX3CR1) ligand is expressed in astrocytes and
reported to be neuroprotective. When cleaved from the membrane, soluble fractalkine …
reported to be neuroprotective. When cleaved from the membrane, soluble fractalkine …
Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury
M Winerdal, ME Winerdal, YQ Wang, BB Fredholm… - Purinergic …, 2016 - Springer
Neonatal brain hypoxic ischemia (HI) often results in long-term motor and cognitive
impairments. Post-ischemic inflammation greatly effects outcome and adenosine receptor …
impairments. Post-ischemic inflammation greatly effects outcome and adenosine receptor …
CX3CL1/CX3CR1 axis plays a key role in ischemia-induced oligodendrocyte injury via p38MAPK signaling pathway
XM Wu, Y Liu, ZM Qian, QQ Luo, Y Ke - Molecular neurobiology, 2016 - Springer
Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of
microglial activation and on the involvement of activated microglia in damaging …
microglial activation and on the involvement of activated microglia in damaging …
Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis
E Ingberg, H Dock, E Theodorsson, A Theodorsson… - Scientific reports, 2016 - nature.com
Although hundreds of promising substances have been tested in clinical trials, thrombolysis
currently remains the only specific pharmacological treatment for ischemic stroke. Poor …
currently remains the only specific pharmacological treatment for ischemic stroke. Poor …
CX3CR1 对缺血性白质的损伤作用
苗晶， 于雪凡， 张颖， 冯加纯 - 中风与神经疾病杂志, 2016 - zfysjjbzz.com
摘要: 目的明确CX3CR1 在缺血性白质中的分布与表达及与缺血性白质损伤的关系. 方法将150
只成年雄性Wistar 大鼠随机分为正常组, 假手术组及缺血组, 采用双侧颈总动脉永久结扎法制备 …
只成年雄性Wistar 大鼠随机分为正常组, 假手术组及缺血组, 采用双侧颈总动脉永久结扎法制备 …