Microglia in the spinal cord and neuropathic pain

M Tsuda - Journal of diabetes investigation, 2016 - Wiley Online Library
In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain–neuropathic pain–is often a …

[HTML][HTML] Astrocytes and microglia and their potential link with autism spectrum disorders

F Petrelli, L Pucci, P Bezzi - Frontiers in cellular neuroscience, 2016 - frontiersin.org
The cellular mechanism (s) underlying autism spectrum disorders (ASDs) are not fully
understood although it has been shown that various genetic and environmental factors …

[HTML][HTML] Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

J Peng, N Gu, L Zhou, UB Eyo, M Murugan… - Nature …, 2016 - nature.com
Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of
neuropathic pain. However, the precise respective function of microglia and peripheral …

[HTML][HTML] Intestinal microbiota in patients with spinal cord injury

B Gungor, E Adiguzel, I Gursel, B Yilmaz, M Gursel - PloS one, 2016 - journals.plos.org
Human intestinal flora comprises thousands of bacterial species. Growth and composition of
intestinal microbiota is dependent on various parameters, including immune mechanisms …

Centrally mediated disorders of gastrointestinal pain

L Keefer, DA Drossman, E Guthrie, M Simrén, K Tillisch… - Gastroenterology, 2016 - Elsevier
Centrally mediated abdominal pain syndrome, formerly known as functional abdominal pain
syndrome, can be distinguished from other functional gastrointestinal disorders by its strong …

[HTML][HTML] Sensitization and interoception as key neurological concepts in osteopathy and other manual medicines

G D'alessandro, F Cerritelli, P Cortelli - Frontiers in neuroscience, 2016 - frontiersin.org
Historically, approaches used in manual medicine to explain patient reported symptoms
have been focused on the so-called exteroceptive paradigm. Arguably, this mindset lacks an …

Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain

X Luo, WL Tai, L Sun, Z Pan, Z Xia, SK Chung… - Molecular …, 2016 - journals.sagepub.com
Background Chemokine axis chemokine CXC motif ligand 12/CXC chemokine receptor type
4 (CXCL12/CXCR4) is an emerging pain modulator, but mechanisms for its involvement in …

[HTML][HTML] Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK

Y Yang, L Hu, Y Xia, C Jiang, C Miao, C Yang… - Journal of …, 2016 - Springer
Background Glial activation and neuroinflammation in the spinal trigeminal nucleus (STN)
play a pivotal role in the genesis and maintenance of trigeminal neuralgia (TN). Resveratrol …

[HTML][HTML] BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit

P Wang, C Du, FX Chen, CQ Li, YB Yu, T Han… - Scientific reports, 2016 - nature.com
The over-expressed colonic brain-derived neurotrophic factor (BDNF) has been reported to
be associated with abdominal pain in patients with irritable bowel syndrome (IBS). However …

Sodium channels in astroglia and microglia

LW Pappalardo, JA Black, SG Waxman - Glia, 2016 - Wiley Online Library
Voltage‐gated sodium channels are required for electrogenesis in excitable cells. Their
activation, triggered by membrane depolarization, generates transient sodium currents that …