Burn patients with concomitant pulmonary Pseudomonas aeruginosa (PA) infection have
mortality rates as high as 50%, despite antibiotic therapy. Sphingosine is generated from …

Background: Hematogenous metastasis of malignant tumor cells is a multistep process that
requires release of tumor cells from the local tumor mass, interaction of the tumor cells with …

Background/Aims: The activation of acid sphingomyelinase by cellular stress or receptors or
the de novo synthesis lead to the formation of ceramide (N-acylsphingosine), which in turn …

Tuberculosis is one of the most serious infectious diseases worldwide. The initial pulmonal
localization of the pathogens often develops into systemic infection with high lethality. We …

Doktorarbeit Stefanie Hönig Page 1 Entwicklung eines Zellkulturmodells zum Nachweis von
Funktion und Substrat der sekretorischen sauren Sphingomyelinase Der Medizinischen …

Ha llegado el momento de agradecer a todos aquellos que en estos años se han cruzado
en mi camino y me han dado la posibilidad de conseguir mi doctorado. Espero ser capaz de …

We have recently suggested a novel mechanism, autoendocytosis, for the entry of certain
microbes into their hosts, with a key role played by the sphingomyelinase-catalyzed topical …

This research investigates the disease-causing ability of Community-acquired and Hospital-
acquired Methicillin-Resistant Staphylococcus aureus (MRSA). This organism is responsible …

The endothelial cells lining vascular and lymphatic vessels are targets of several infectious
agents, including viruses, bacteria, fungi, and parasites that lead to dramatic changes in …

CONTENTS 13.1 Introduction 299 13.2 MRs and eir Clustering 300 13.2. 1 Nature and
Behaviour of MRs 301 13.2. 2 Caveolar and Non-Caveolar MRs 302 13.2. 3 Ceramide …