A global genetic interaction network maps a wiring diagram of cellular function
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
Chemical tools to investigate mechanisms associated with HSP90 and HSP70 in disease
The chaperome is a large and diverse protein machinery composed of chaperone proteins
and a variety of helpers, such as the co-chaperones, folding enzymes, and scaffolding and …
and a variety of helpers, such as the co-chaperones, folding enzymes, and scaffolding and …
Hsp90: a global regulator of the genotype-to-phenotype map in cancers
D Jarosz - Advances in cancer research, 2016 - Elsevier
Cancer cells have the unusual capacity to limit the cost of the mutation load that they harbor
and simultaneously harness its evolutionary potential. This property fuels drug resistance, a …
and simultaneously harness its evolutionary potential. This property fuels drug resistance, a …
Hsp90 and physiological stress are linked to autonomous transposon mobility and heritable genetic change in nematodes
CP Ryan, JC Brownlie, S Whyard - Genome biology and …, 2016 - academic.oup.com
Transposable elements (TEs) have been recognized as potentially powerful drivers of
genomic evolutionary change, but factors affecting their mobility and regulation remain …
genomic evolutionary change, but factors affecting their mobility and regulation remain …
Cryptic genetic variation in evolutionary developmental genetics
Evolutionary developmental genetics has traditionally been conducted by two groups:
Molecular evolutionists who emphasize divergence between species or higher taxa, and …
Molecular evolutionists who emphasize divergence between species or higher taxa, and …
HSP90 stabilizes auxin-responsive phenotypes by masking a mutation in the auxin receptor TIR1
E Watanabe, S Mano, M Nomoto, Y Tada… - Plant and Cell …, 2016 - academic.oup.com
Heat shock protein 90 (HSP90) is a molecular chaperone that is required for the function of
various substrate proteins, also known as client proteins. It is proposed that HSP90 buffers …
various substrate proteins, also known as client proteins. It is proposed that HSP90 buffers …
Developmental patterning as a quantitative trait: genetic modulation of the Hoxb6 mutant skeletal phenotype
C Kappen - PloS one, 2016 - journals.plos.org
The process of patterning along the anterior-posterior axis in vertebrates is highly
conserved. The function of Hox genes in the axis patterning process is particularly well …
conserved. The function of Hox genes in the axis patterning process is particularly well …
Hsp90 maintains proteostasis of the galactose utilization pathway to prevent cell lethality
RK Gopinath, JY Leu - Molecular and cellular biology, 2016 - Taylor & Francis
Hsp90 is a molecular chaperone that aids in the folding of its metastable client proteins. Past
studies have shown that it can exert a strong impact on some cellular pathways by …
studies have shown that it can exert a strong impact on some cellular pathways by …
Unapređenje ključnih indikatora performansi poslovanja u industriji livarstva
AI Jovičić - Универзитет у Крагујевцу, 2016 - nardus.mpn.gov.rs
Unapređenje ključnih indikatora perofrmansi poslovanja u industriji livarstva radi dostizanja
globalnih standarda procesne i resursne efikasnosti od opšteg je interesa za srpske livnice s …
globalnih standarda procesne i resursne efikasnosti od opšteg je interesa za srpske livnice s …
The emergence of Physiology and Form: Natural selection revisited
JS Torday - Biology, 2016 - mdpi.com
Natural Selection describes how species have evolved differentially, but it is descriptive, non-
mechanistic. What mechanisms does Nature use to accomplish this feat? One known way in …
mechanistic. What mechanisms does Nature use to accomplish this feat? One known way in …