Emerging frontiers in drug delivery
Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …
Recent progress in development of siRNA delivery vehicles for cancer therapy
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure
Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …
Polymer–lipid nanoparticles for systemic delivery of mRNA to the lungs
Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors
for safe and effective delivery. Synthetic nanoparticle vectors composed of poly (β‐amino …
for safe and effective delivery. Synthetic nanoparticle vectors composed of poly (β‐amino …
[PDF][PDF] Fusogenic reactive oxygen species triggered charge‐reversal vector for effective gene delivery
DOI: 10.1002/adma. 201504288 a reactive oxygen species (ROS)-labile charge-reversal
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B …
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B …
Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
MicroRNAs (miRNAs) are being developed to enhance tissue regeneration. Here we show
that a hyperbranched polymer with high miRNA-binding affinity and negligible cytotoxicity …
that a hyperbranched polymer with high miRNA-binding affinity and negligible cytotoxicity …
Nanomedicines for renal disease: current status and future applications
N Kamaly, JC He, DA Ausiello… - Nature Reviews …, 2016 - nature.com
Abstract Treatment and management of kidney disease currently presents an enormous
global burden, and the application of nanotechnology principles to renal disease therapy …
global burden, and the application of nanotechnology principles to renal disease therapy …
Effect of surface properties on liposomal siRNA delivery
Liposomes are one of the most widely investigated carriers for siRNA delivery. The surface
properties of liposomal carriers, including the surface charge, PEGylation, and ligand …
properties of liposomal carriers, including the surface charge, PEGylation, and ligand …
Esterase‐activated charge‐reversal polymer for fibroblast‐exempt cancer gene therapy
(Figure 1a). Taking advantage of the high cytosolic esterase activity in HeLa cancer cells but
low level in fibroblasts, the ERP/DNA polyplexes taken up by cancer cells quickly dissociate …
low level in fibroblasts, the ERP/DNA polyplexes taken up by cancer cells quickly dissociate …
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
Abstract mRNA has broad potential for treating diseases requiring protein expression.
However, mRNA can also induce an immune response with associated toxicity …
However, mRNA can also induce an immune response with associated toxicity …