Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Lung surfactant is a complex with a unique phospholipid and protein composition. Its
specific function is to reduce surface tension at the pulmonary air–liquid interface. The …

A randomized trial (VITACOG) in people with mild cognitive impairment (MCI) found that B
vitamin treatment to lower homocysteine slowed the rate of cognitive and clinical decline …

Lipidomics of human blood plasma is an emerging biomarker discovery approach that
compares lipid profiles under pathological and physiologically normal conditions, but how a …

Although single nucleotide polymorphisms (SNPs) in folate-mediated pathways predict
susceptibility to choline deficiency during severe choline deprivation, it is unknown if effects …

Following a request from the European Commission, the EFSA Panel on Dietetic Products,
Nutrition and Allergies (NDA) derives Dietary Reference Values (DRV s) for choline. In this …

Abstract Background Docosahexaenoic (C22: 6) and arachidonic acid (C20: 4) are long-
chain polyunsaturated fatty acids (LC-PUFA), essential to fetal development, and …

Balance of labile methyl groups (choline, methionine, betaine, and folate) is important for
normal liver function. Quantitatively, a significant use of labile methyl groups is in the …

Background Lysinuric protein intolerance (LPI [MIM 222700]) is an aminoaciduria with
defective transport of cationic amino acids in epithelial cells in the small intestine and …

Background and Aims Vitamin B 12 and omega-3 fatty acid deficiency is prevalent in the
vegetarian population and is associated with adverse pregnancy outcomes and …