In Vitro and In Vivo Biofilm Wound Models and Their Application

G Brackman, T Coenye - … in Microbiology, Infectious Diseases and Public …, 2016 - Springer
Chronic wounds are wounds which are detained in one or more phases of normal wound
healing. It is estimated that 1–2% of the population of developed countries will experience a …

Update on the role of infection and biofilms in wound healing: pathophysiology and treatment

M Gompelman, SAV van Asten… - Plastic and reconstructive …, 2016 - journals.lww.com
Background: Chronic wounds, and among these infected diabetic foot ulcers, are a
worldwide problem. The poor treatment outcomes result in high healthcare costs …

Exacerbated and prolonged inflammation impairs wound healing and increases scarring

LW Qian, AB Fourcaudot, K Yamane… - Wound repair and …, 2016 - Wiley Online Library
Altered inflammation in the early stage has long been assumed to affect subsequent steps of
the repair process that could influence proper wound healing and remodeling. However, the …

Microbiota is a primary cause of pathogenesis of chronic wounds

R Wolcott, N Sanford, R Gabrilska… - Journal of wound …, 2016 - magonlinelibrary.com
Objective: Diverse microorganisms present on the surface of chronic wounds have been
established to constitute wound microbiota. The aims of this study were to quantify the …

Extracellular bacterial proteases in chronic wounds: a potential therapeutic target?

L Suleman - Advances in wound care, 2016 - liebertpub.com
Significance: Bacterial biofilms are considered to be responsible for over 80% of persistent
infections, including chronic lung infections, osteomyelitis, periodontitis, endocarditis, and …

Hydroxyapatite microporous bioceramics as vancomycin reservoir: antibacterial efficiency and biocompatibility investigation

M Parent, A Magnaudeix… - Journal of …, 2016 - journals.sagepub.com
Infections after bone reconstructive surgery are a real therapeutic and economic issue for
the modern health care system. As the pathogen (most often Staphylococcus aureus) is able …

[HTML][HTML] Early application of negative pressure wound therapy to acute wounds contaminated with Staphylococcus aureus: an effective approach to preventing biofilm …

T Li, L Zhang, LI Han, G Wang… - Experimental and …, 2016 - spandidos-publications.com
Negative pressure wound therapy (NPWT) has been demonstrated to be effective at
preventing biofilm-associated infections; however, its role in biofilm prevention is unknown …

Animal models of chronic wound care: the application of biofilms in clinical research

H Trøstrup, K Thomsen, H Calum, N Høiby… - Chronic Wound Care …, 2016 - Taylor & Francis
Chronic wounds are a substantial clinical problem affecting millions of people worldwide.
Pathophysiologically, chronic wounds are stuck in the inflammatory state of healing. The role …

Clinician perceptions of wound biofilm

DG Metcalf, PG Bowler - International wound journal, 2016 - Wiley Online Library
In wound care today, biofilm is a subject area of great interest and debate. There is an
increasing awareness that biofilm exists in the majority of non‐healing wounds, and that it is …

Safety and performance evaluation of a next‐generation antimicrobial dressing in patients with chronic venous leg ulcers

KG Harding, M Szczepkowski… - International Wound …, 2016 - Wiley Online Library
The objective of this study was to investigate the safety and performance of AQUACEL™
Ag+ dressing, a wound dressing containing a combination of anti‐biofilm and antimicrobial …