Antibiotic perturbation of the preterm infant gut microbiome and resistome

AJ Gasparrini, TS Crofts, MK Gibson, PI Tarr… - Gut …, 2016 - Taylor & Francis
The gut microbiota plays important roles in nutrient absorption, immune system
development, and pathogen colonization resistance. Perturbations early in life may be …

The significance of the enteric microbiome on the development of childhood disease: a review of prebiotic and probiotic therapies in disorders of childhood

J Slattery, DF MacFabe… - Clinical Medicine Insights …, 2016 - journals.sagepub.com
Recent studies have highlighted the fact that the enteric microbiome, the trillions of microbes
that inhabit the human digestive tract, has a significant effect on health and disease …

Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease

CJ Stewart, ND Embleton, ECL Marrs, DP Smith… - Microbiome, 2016 - Springer
Background The preterm microbiome is crucial to gut health and may contribute to
necrotising enterocolitis (NEC), which represents the most significant pathology affecting …

Necrotizing enterocolitis and preterm infant gut bacteria

BB Warner, PI Tarr - Seminars in Fetal and Neonatal Medicine, 2016 - Elsevier
Necrotizing enterocolitis remains an intractable consequence of preterm birth. Gut microbial
communities, especially bacterial communities, have long been suspected to play a role in …

Metabolomics in necrotizing enterocolitis: the state of the art

A Dessì, R Pintus, S Marras… - Expert Review of …, 2016 - Taylor & Francis
Introduction: Necrotizing enterocolitis (NEC) is a serious inflammation of the bowel that most
often affects premature infants. The exact cause of NEC is still poorly understood but …

Transitioning from descriptive to mechanistic understanding of the microbiome: the need for a prospective longitudinal approach to predicting disease

VJ Martin, MM Leonard, L Fiechtner… - The Journal of pediatrics, 2016 - jpeds.com
The incidences of chronic inflammatory diseases are rising dramatically in the developed
world, with increasing disease burdens in childhood. 1 Currently there are limited effective …

Gut microbiota dysbiosis precedes NEC

H Thomas - Nature Reviews Gastroenterology & Hepatology, 2016 - nature.com
Infants weighing< 1,500 g at birth who go on to develop necrotizing enterocolitis (NEC) are
more likely to have preceding gut microbiota dysbiosis than infants who do not develop the …

Gut microbiome and necrotising enterocolitis: time for intervention?

A Fasano - The Lancet, 2016 - thelancet.com
To capitalise on the wealth of data generated by studies like the one published in The
Lancet and to create personalised, targeted interventions, the challenge for researchers is to …

[引用][C] GUT FEELINGS: INVESTIGATING THE LINKS BETWEEN ACUTE GASTROINTESTINAL ILLNESS AND MENTAL HEALTH

JH ZANIN - 2016