The neural crest (NC) is a remarkable transient structure generated during early vertebrate
development. The neural crest progenitors have extensive migratory capacity and …

Hirschsprung's disease (HSCR) is neonatal intestinal abnormality which derived from the
faliure of enteric neural crest cells migration to hindgut during embryogenesis from 5 to 12 …

Background Transplanting autologous patient‐derived enteric neuronal stem/progenitor
cells (ENSC s) is an innovative approach to replacing missing enteric neurons in patients …

Neural crest stem cells (NCSCs) represent a transient and multipotent cell population that
contributes to numerous anatomical structures such as peripheral nervous system, teeth …

Fryns syndrome is an autosomal recessive condition characterized by congenital
diaphragmatic hernia (CDH), dysmorphic facial features, distal digital hypoplasia, and other …

The enteric nervous system (ENS) is required for peristalsis of the gut and is derived from
Enteric Neural Crest Cells (ENCCs). During ENS development, the RET receptor tyrosine …

Background: Hirschsprung disease is a complex genetic disorder of the enteric nervous
system (ENS), often called congenital aganglionic megacolon and characterized by the …

Mutations in the BAF complex (mammalian SWI/SNF complex) are responsible for Coffin‐
Siris syndrome, which is characterized by developmental delay, distinctive facial features …

Abstract Endothelin-3 (EDN3) and β1-integrins are required for the colonization of the
embryonic gut by enteric neural crest cells (ENCCs) to form the enteric nervous system …

Hirschsprung disease (HD) in late childhood is uncommon and often undiagnosed or
misdiagnosed. However, in a patient with Hirschsprung disease, of greater significance is …