Objective: There is burgeoning interest in augmentation strategies for improving inadequate
response to antidepressants. The adjunctive use of standardized pharmaceutical-grade …

Major depressive disorder (MDD) is a debilitating disease that is characterized by
depressed mood, diminished interests, impaired cognitive function and vegetative …

Background Depression is a recurrent illness with high rates of chronicity, treatment‐
resistance and significant economic impact. There is evidence in the literature that S …

Depression is the most common complication of childbirth and results in adverse health
outcomes for both mother and child. It is vital, therefore, that health professionals be ready to …

Objective. To review the antidepressant efficacy of S-Adenosyl-L-Methionine (SAMe) both in
monotherapy and/or in augmentation with antidepressants to better understand its potential …

Cognitive dysfunction is increasingly being recognized as an important clinical dimension in
major depressive disorder. This review summarizes the existing data on the epidemiology …

Epigenetic mechanisms are believed to link environmental exposures to gene expression,
and in so doing, to provide a physical basis for the activation, by life experiences, of mental …

Preclinical Research S‐adenosyl methionine (SAM) is a major methyl donor and as such
exerts its influence on CNS function through methylation reactions, such as methylation of …

Depression is one of the leading causes of mental disability worldwide and a significant
public health problem in the United States. Individuals with depression have lower quality of …

In this Seminar we discuss developments from the past 5 years in the diagnosis,
neurobiology, and treatment of major depressive disorder. For diagnosis, psychiatric and …