Total HIV-1 DNA, a marker of viral reservoir dynamics with clinical implications
V Avettand-Fènoël, L Hocqueloux… - Clinical microbiology …, 2016 - Am Soc Microbiol
SUMMARY HIV-1 DNA persists in infected cells despite combined antiretroviral therapy
(cART), forming viral reservoirs. Recent trials of strategies targeting latent HIV reservoirs …
(cART), forming viral reservoirs. Recent trials of strategies targeting latent HIV reservoirs …
The gut microbiome and HIV-1 pathogenesis: a two-way street
HIV-1 infection is associated with substantial damage to the gastrointestinal tract resulting in
structural impairment of the epithelial barrier and a disruption of intestinal homeostasis. The …
structural impairment of the epithelial barrier and a disruption of intestinal homeostasis. The …
Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy
SN Byrareddy, J Arthos, C Cicala, F Villinger, KT Ortiz… - Science, 2016 - science.org
Antiretroviral drug therapy (ART) effectively suppresses replication of both the
immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon …
immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon …
Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral …
C Tincati, E Merlini, P Braidotti, G Ancona, F Savi… - Aids, 2016 - journals.lww.com
Objective: HIV-infected individuals with incomplete CD4+ T-cell recovery upon combination
antiretroviral therapy (cART) display high levels of immune activation and microbial …
antiretroviral therapy (cART) display high levels of immune activation and microbial …
Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection
SM Dillon, EJ Lee, AM Donovan, K Guo, MS Harper… - Retrovirology, 2016 - Springer
Background Early HIV-1 infection is characterized by high levels of HIV-1 replication and
substantial CD4 T cell depletion in the intestinal mucosa, intestinal epithelial barrier …
substantial CD4 T cell depletion in the intestinal mucosa, intestinal epithelial barrier …
Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection
Loss of immune control over opportunistic infections can occur at different stages of HIV-1
(HIV) disease, among which mucosal candidiasis caused by the fungal pathogen Candida …
(HIV) disease, among which mucosal candidiasis caused by the fungal pathogen Candida …
The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that …
K Raehtz, I Pandrea, C Apetrei - Infection, Genetics and Evolution, 2016 - Elsevier
African NHPs are infected by over 40 different simian immunodeficiency viruses. These
viruses have coevolved with their hosts for long periods of time and, unlike HIV in humans …
viruses have coevolved with their hosts for long periods of time and, unlike HIV in humans …
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed …
SM Gonzalez, NA Taborda, LA Correa, GA Castro… - Immunologic …, 2016 - Springer
The spontaneous control of HIV replication in HIV-controllers underlines the importance of
these subjects for exploring factors related to delayed progression. Several studies have …
these subjects for exploring factors related to delayed progression. Several studies have …
HIV-1 gp120: a target for therapeutics and vaccine design
C Cicala, F Nawaz, K Jelicic, J Arthos… - Current Drug …, 2016 - ingentaconnect.com
Although extraordinary progress has been made in the treatment and prevention of HIV
infection, the AIDS pandemic continues to rage globally with 2.1 million infections and 1.6 …
infection, the AIDS pandemic continues to rage globally with 2.1 million infections and 1.6 …
CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals
J Zaunders, M Danta, M Bailey, G Mak… - Frontiers in …, 2016 - frontiersin.org
Background Disruption of gastrointestinal tract epithelial and immune barriers contribute to
microbial translocation, systemic inflammation, and progression of HIV-1 infection …
microbial translocation, systemic inflammation, and progression of HIV-1 infection …