Targeting CK2-driven non-oncogene addiction in B-cell tumors
Genetic mutations of oncogenes often underlie deranged cell growth and altered
differentiation pathways leading to malignant transformation of B-lymphocytes. However …
differentiation pathways leading to malignant transformation of B-lymphocytes. However …
Protein kinase CK2α maintains extracellular signal-regulated kinase (ERK) activity in a CK2α kinase-independent manner to promote resistance to inhibitors of RAF …
B Zhou, DA Ritt, DK Morrison, CJ Der… - Journal of Biological …, 2016 - ASBMB
The protein kinase casein kinase 2 (CK2) is a pleiotropic and constitutively active kinase that
plays crucial roles in cellular proliferation and survival. Overexpression of CK2, particularly …
plays crucial roles in cellular proliferation and survival. Overexpression of CK2, particularly …
Discovery and optimization of macrocyclic quinoxaline-pyrrolo-dihydropiperidinones as potent pim-1/2 kinase inhibitors
VJ Cee, F Chavez Jr, B Herberich… - ACS Medicinal …, 2016 - ACS Publications
The identification of Pim-1/2 kinase overexpression in B-cell malignancies suggests that Pim
kinase inhibitors will have utility in the treatment of lymphoma, leukemia, and multiple …
kinase inhibitors will have utility in the treatment of lymphoma, leukemia, and multiple …
[HTML][HTML] Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 …
Abstract Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development
and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated …
and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated …
[HTML][HTML] Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer …
H Kulbe, F Iorio, P Chakravarty, CS Milagre, R Moore… - Oncotarget, 2016 - ncbi.nlm.nih.gov
We previously showed how key pathways in cancer-related inflammation and Notch
signaling are part of an autocrine malignant cell network in ovarian cancer. This network …
signaling are part of an autocrine malignant cell network in ovarian cancer. This network …
[PDF][PDF] OptimalIL-7R-mediatedsignaling, cellcycleprogressionandviabilityofT-cellacute lymphoblasticleukemiacellsrelyonCK2activity
Interleukin-7 and IL7R are essential for normal T-cell development and homeostasis,
whereas excessive interleukin-7/IL7R-mediated signaling promotes leukemogenesis …
whereas excessive interleukin-7/IL7R-mediated signaling promotes leukemogenesis …