[HTML][HTML] DREADDs for neuroscientists
BL Roth - Neuron, 2016 - cell.com
To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …
normal and pathological brain function. In this regard, chemogenetic technologies represent …
DREADDS: Use and application in behavioral neuroscience.
Technological advances over the last decade are changing the face of behavioral
neuroscience research. Here we review recent work on the use of one such transformative …
neuroscience research. Here we review recent work on the use of one such transformative …
Clozapine N-oxide administration produces behavioral effects in Long–Evans rats: implications for designing DREADD experiments
Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can
selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively …
selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively …
[HTML][HTML] Architectural representation of valence in the limbic system
In order to thrive, animals must be able to recognize aversive and appetitive stimuli within
the environment and subsequently initiate appropriate behavioral responses. This …
the environment and subsequently initiate appropriate behavioral responses. This …
Chemogenetic activation of an extinction neural circuit reduces cue-induced reinstatement of cocaine seeking
IF Augur, AR Wyckoff, G Aston-Jones… - Journal of …, 2016 - Soc Neuroscience
The ventromedial prefrontal cortex (vmPFC) has been shown to negatively regulate cocaine-
seeking behavior, but the precise conditions by which vmPFC activity can be exploited to …
seeking behavior, but the precise conditions by which vmPFC activity can be exploited to …
Role of ventral subiculum in context-induced relapse to alcohol seeking after punishment-imposed abstinence
In many human alcoholics, abstinence is self-imposed because of the negative
consequences of excessive alcohol use, and relapse is often triggered by exposure to …
consequences of excessive alcohol use, and relapse is often triggered by exposure to …
[HTML][HTML] Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
Multiple autism risk genes converge on the regulation of mTOR signalling, which is a key
effector of neuronal growth and connectivity. We show that mTOR signalling is dysregulated …
effector of neuronal growth and connectivity. We show that mTOR signalling is dysregulated …
Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation
AJ López, E Kramár, DP Matheos… - Journal of …, 2016 - Soc Neuroscience
Designer receptors exclusively activated by designer drug (DREADDs) are a novel tool with
the potential to bidirectionally drive cellular, circuit, and ultimately, behavioral changes. We …
the potential to bidirectionally drive cellular, circuit, and ultimately, behavioral changes. We …
[HTML][HTML] Chemogenetic inactivation of dorsal anterior cingulate cortex neurons disrupts attentional behavior in mouse
H Koike, MP Demars, JA Short, EM Nabel… - …, 2016 - nature.com
Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains
limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC) …
limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC) …
Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats
L Boekhoudt, A Omrani, MCM Luijendijk… - European …, 2016 - Elsevier
Hyperactivity is a core symptom in various psychiatric disorders, including attention-
deficit/hyperactivity disorder, schizophrenia, bipolar disorders, and anorexia nervosa …
deficit/hyperactivity disorder, schizophrenia, bipolar disorders, and anorexia nervosa …