The skeletal muscle is subjected to high mechanical and energetic demands. Lipid droplets
are an important source of energy substrates for the working muscle. Muscle cells contain a …

Context: Adipocytes represent an important insulin-responsive tissue taking an active part in
glucose metabolism. Objective: This study sought to assess adipose tissue insulin …

(Holland et al. 2007). r Genetic ablation of ceramide synthase 6, which is involved in the
third step in the biosynthetic pathway, prevents insulin resistance in mice fed a high fat diet …

Purpose The goal of this study was to explore the effect of lifelong aerobic exercise (ie
chronic training) on skeletal muscle substrate stores (intramyocellular triglyceride [IMTG] and …

Introduction/hypothesis Disturbances in skeletal muscle fatty acid (FA) handling may
contribute to the development and progression of whole-body insulin resistance (IR). In this …

The paper demonstrates that minute‐to‐minute metabolic response to meals with different
macronutrient content can be measured and discerned in the whole‐body indirect …

Multiple studies have shown the effects of long-term exposure to high-fat or western diets on
the vascular system. There is limited knowledge on the acute effects of high circulating fat …

Peterson and Jurczak identified two lines of evidence to question roles for ceramides in
insulin resistance. The first relates to discordance between lipidomic profiling studies …

Continual intake of high-fat foods, coupled with limited physical activity, can lead to
metabolic inflexibility. Eventually, this may lead to significant health issues such as obesity …

Úvod: Diabetes mellitus 1. typu, onemocnění charakterizované absolutní inzulinovou
deficiencí, je spjat se zvýšenou absorpcí cholesterolu. Obezita je provázena sníženou …