[HTML][HTML] Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential
A Kazanets, T Shorstova, K Hilmi, M Marques… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …
there are a number of universal aberrations common to all cancers, one of these being the …
Establishment and functions of DNA methylation in the germline
KR Stewart, L Veselovska, G Kelsey - Epigenomics, 2016 - Taylor & Francis
Epigenetic modifications established during gametogenesis regulate transcription and other
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells
The 18-kb Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation
during female eutherian mammalian development. Global structural architecture, cell …
during female eutherian mammalian development. Global structural architecture, cell …
Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …
Evolution of epigenetic regulation in vertebrate genomes
Empirical models of sequence evolution have spurred progress in the field of evolutionary
genetics for decades. We are now realizing the importance and complexity of the eukaryotic …
genetics for decades. We are now realizing the importance and complexity of the eukaryotic …
Epigenome-wide association analysis identified nine skin DNA methylation loci for psoriasis
F Zhou, W Wang, C Shen, H Li, X Zuo, X Zheng… - Journal of Investigative …, 2016 - Elsevier
Psoriasis is a chronic hyperproliferative and inflammatory skin disease caused by the
interplay of genetic and environmental factors. DNA methylation has been linked to …
interplay of genetic and environmental factors. DNA methylation has been linked to …
Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction
S Pfeiffer, J Krüger, A Maierhofer, Y Böttcher… - Scientific reports, 2016 - nature.com
Recently, a genome-wide analysis identified DNA methylation of the HIF3A (hypoxia-
inducible factor 3A) as strongest correlate of BMI. Here we tested the hypothesis that HIF3A …
inducible factor 3A) as strongest correlate of BMI. Here we tested the hypothesis that HIF3A …
[HTML][HTML] Epigenetic response to environmental stress: Assembly of BRG1–G9a/GLP–DNMT3 repressive chromatin complex on Myh6 promoter in pathologically …
Chromatin structure is determined by nucleosome positioning, histone modifications, and
DNA methylation. How chromatin modifications are coordinately altered under pathological …
DNA methylation. How chromatin modifications are coordinately altered under pathological …
ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells
Abstract Imprinting Control Regions (ICRs) need to maintain their parental allele-specific
DNA methylation during early embryogenesis despite genome-wide demethylation and …
DNA methylation during early embryogenesis despite genome-wide demethylation and …