[HTML][HTML] Reference-free deconvolution of DNA methylation data and mediation by cell composition effects
Background Recent interest in reference-free deconvolution of DNA methylation data has
led to several supervised methods, but these methods do not easily permit the interpretation …
led to several supervised methods, but these methods do not easily permit the interpretation …
[HTML][HTML] Epigenomic deconvolution of breast tumors reveals metabolic coupling between constituent cell types
V Onuchic, RJ Hartmaier, DN Boone, ML Samuels… - Cell reports, 2016 - cell.com
Cancer progression depends on both cell-intrinsic processes and interactions between
different cell types. However, large-scale assessment of cell type composition and molecular …
different cell types. However, large-scale assessment of cell type composition and molecular …
[HTML][HTML] Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon …
Objective Previous studies have shown that differential DNA methylation is associated with
SLE susceptibility. How DNA methylation affects the clinical heterogeneity of SLE has not …
SLE susceptibility. How DNA methylation affects the clinical heterogeneity of SLE has not …
Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates
S Gonseth, AJ de Smith, R Roy, M Zhou, ST Lee… - Epigenetics, 2016 - Taylor & Francis
Epigenome-wide DNA methylation association studies have identified highly replicable
genomic loci sensitive to maternal smoking during gestation. The role of inter-individual …
genomic loci sensitive to maternal smoking during gestation. The role of inter-individual …