Genetics of coronary artery disease

R McPherson, A Tybjaerg-Hansen - Circulation research, 2016 - Am Heart Assoc
Genetic factors contribute importantly to the risk of coronary artery disease (CAD), and in the
past decade, there has been major progress in this area. The tools applied include genome …

Genetics: implications for prevention and management of coronary artery disease

TL Assimes, R Roberts - Journal of the American College of cardiology, 2016 - jacc.org
An exciting new era has dawned for the prevention and management of coronary artery
disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …

[HTML][HTML] Genomics is failing on diversity

AB Popejoy, SM Fullerton - Nature, 2016 - nature.com
Genomics is failing on diversity | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Genetics of type 2 diabetes

A Stančáková, M Laakso - Novelties in Diabetes, 2016 - karger.com
Genetic and environmental factors as well as their interactions contribute to the
pathogenesis of type 2 diabetes. Linkage analysis, candidate gene approaches, genome …

[HTML][HTML] Strategies for enriching variant coverage in candidate disease loci on a multiethnic genotyping array

SA Bien, GL Wojcik, N Zubair, CR Gignoux, AR Martin… - PloS one, 2016 - journals.plos.org
Investigating genetic architecture of complex traits in ancestrally diverse populations is
imperative to understand the etiology of disease. However, the current paucity of genetic …

[HTML][HTML] Causal role of alcohol consumption in an improved lipid profile: the atherosclerosis risk in communities (ARIC) study

KN Vu, CM Ballantyne, RC Hoogeveen, V Nambi… - PloS one, 2016 - journals.plos.org
Introduction Health benefits of low-to-moderate alcohol consumption may operate through
an improved lipid profile. A Mendelian randomization (MR) approach was used to examine …

[HTML][HTML] Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs

JE Below, EJ Parra, ER Gamazon, J Torres… - Scientific reports, 2016 - nature.com
We performed genome-wide meta-analysis of lipid traits on three samples of Mexican and
Mexican American ancestry comprising 4,383 individuals and followed up significant and …

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

J Gupta, E Johansson, JA Bernstein… - Journal of Allergy and …, 2016 - Elsevier
Atopic dermatitis (AD), food allergy, allergic rhinitis, and asthma are common atopic
disorders of complex etiology. The frequently observed atopic march from early AD to …

[HTML][HTML] Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank

W Gan, RG Walters, MV Holmes, F Bragg, IY Millwood… - Diabetologia, 2016 - Springer
Aims/hypothesis Genome-wide association studies (GWAS) have discovered many risk
variants for type 2 diabetes. However, estimates of the contributions of risk variants to type 2 …

Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

DS Evans, CL Avery, MA Nalls, G Li… - Human molecular …, 2016 - academic.oup.com
The electrocardiographic QRS duration, a measure of ventricular depolarization and
conduction, is associated with cardiovascular mortality. While single nucleotide …