Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

Iron is an essential dietary element. However, the ability of iron to cycle between oxidized
and reduced forms also renders it capable of contributing to free radical formation, which …

Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various
human diseases, including ischemic organ damage and cancer. Here, we report the crucial …

Macroautophagy/autophagy is an evolutionarily conserved degradation pathway that
maintains homeostasis. Ferroptosis, a novel form of regulated cell death, is characterized by …

Autophagy has burgeoned rapidly as a field of study because of its evolutionary
conservation, the diversity of intracellular cargoes degraded and recycled by this machinery …

Selective autophagy contributes to intracellular homeostasis by mediating the degradation
of cytoplasmic material such as aggregated proteins, damaged or over-abundant …

The cargo receptor NCOA4 mediates autophagic ferritin degradation. Here we show that
NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and …

The living cell is an ever changing, responsive, and adaptive environment where proteins
play key roles in all processes and functions. While the scientific community focused for a …

Selective autophagy is critical for regulating cellular homeostasis by mediating lysosomal
turnover of a wide variety of substrates including proteins, aggregates, organelles, and …

In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where
ferrochelatase inserts Fe 2+ into protoporphyrin IX. However, the path of iron from …