Abstract Lifestyle choices influence 20–40% of adult peak bone mass. Therefore,
optimization of lifestyle factors known to influence peak bone mass and strength is an …

The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …

Mapping perturbed molecular circuits that underlie complex diseases remains a great
challenge. We developed a comprehensive resource of 394 cell type–and tissue-specific …

Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts,
osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density …

Inhibition of the Wnt antagonist sclerostin increases bone mass in patients with osteoporosis
and in preclinical animal models. Here we show increased levels of the Wnt antagonist …

Abstract The Longitudinal Aging Study Amsterdam (LASA) is an ongoing longitudinal study
of older adults in the Netherlands, which started in 1992. LASA is focused on the …

Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …

Intracranial volume reflects the maximally attained brain size during development, and
remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes …