Advancements in zebrafish applications for 21st century toxicology

GR Garcia, PD Noyes, RL Tanguay - Pharmacology & therapeutics, 2016 - Elsevier
The zebrafish model is the only available high-throughput vertebrate assessment system,
and it is uniquely suited for studies of in vivo cell biology. A sequenced and annotated …

Using zebrafish in systems toxicology for developmental toxicity testing

Y Nishimura, A Inoue, S Sasagawa… - Congenital …, 2016 - Wiley Online Library
With the high cost and the long‐term assessment of developmental toxicity testing in
mammals, the vertebrate zebrafish has become a useful alternative model organism for high …

Heteroleptic mononuclear compounds of ruthenium (ii): Synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos

OA Lenis-Rojas, AR Fernandes… - Dalton …, 2016 - pubs.rsc.org
The limitations of platinum complexes in cancer treatment have motivated the extensive
investigation into other metal complexes such as ruthenium. We herein present the …

Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking

K Makarova, P Siudem, K Zawada, J Kurkowiak - Zebrafish, 2016 - liebertpub.com
Bisphenol A (BPA) acts as an endocrine-disrupting compound even at a low concentration.
Degradation of BPA could lead to the formation of toxic products. In this study, we compare …

The Complete and Updated

C Lawrence, J Best, J Cockington, EC Henry… - JoVE (Journal of …, 2016 - jove.com
The zebrafish (Danio rerio) is a model organism of increasing importance in many fields of
science. One of the most demanding technical aspects of culture of this species in the …

Hazard assessment of polycyclic aromatic hydrocarbons in water and sediment in the vicinity of coalmines

MP Seopela, RI McCrindle, S Combrinck… - Journal of Soils and …, 2016 - Springer
Purpose Rivers feeding into the Loskop Dam, South Africa, pass through coal mining and
heavily industrialised areas. Previous studies investigating mass mortalities of crocodile and …

环境毒理学研究的重要模式生物--斑马鱼

孙冰, 许慧慧, 黄超, 丁训城, 李卫华, 胡晶莹 - 环境与职业医学, 2016 - cqvip.com
斑马鱼被广泛应用于环境化学物的监测与评价, 并得到经济合作发展组织(OECD),
国际标准化组织(ISO) 等权威机构的认可. 本文简述了斑马鱼应用于环境毒理学研究的诸多优势 …

Osteogenic Differentiation of Human Embryonic Stem Cell-Derived Mesenchymal Progenitor Cells as a Model for Assessing Developmental Bone Toxicity In Vitro

D Sittner, B Huhse, M Steinfath, A Luch… - Applied In Vitro …, 2016 - liebertpub.com
The assessment of adverse effects of substances on human embryonic bone formation is an
integral part of regulatory in vivo studies that cover prenatal developmental toxicity. One of …

Development of a quantitative morphological assessment of toxicant‐treated zebrafish larvae using brightfield imaging and high‐content analysis

S Deal, J Wambaugh, R Judson… - Journal of Applied …, 2016 - Wiley Online Library
One of the rate‐limiting procedures in a developmental zebrafish screen is the
morphological assessment of each larva. Most researchers opt for a time‐consuming …

In vitro screening methods for developmental toxicology

RG Ellis-Hutchings, E de Jong… - Developmental and …, 2016 - taylorfrancis.com
Traditional mammalian in vivo assays directed at characterizing the hazard potential of a test
agent during the development of an embryo are intensive in time, technical resources …