Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

Leishmaniasis is endemic in 98 countries and territories worldwide. The therapies available
for leishmaniasis have serious side effects, thus prompting the search for new therapies. The …

Despite ongoing efforts, the available treatments for Chagas' disease are still unsatisfactory,
especially in the chronic phase of the disease. Our previous study reported the strong …

This work evaluated the in vitro and in vivo activity of TDZ 2 on Trypanosoma cruzi
amastigotes and determined the possible mechanism of action of this compound on T. cruzi …

Leishmaniasis is a neglected infection that is caused by Leishmania protozoa, affecting
millions of people worldwide, mainly in tropical and subtropical regions. This disease has …

Drug repositioning, ie. use of existing medicals to treat a different illness, is especially
rewarding for neglected tropical diseases (NTD), since in this field the pharmaceutical …

Summary Malaria, human African trypanosomiasis, Chagas and leishmaniasis are four
protozoan tropical infectious diseases that remain a global public health problem with …

Leishmania spp. are protozoa responsible for leishmaniasis, a neglected disease that kills
up to 50,000 people every year. Current therapies mainly rely on antimonial drugs that are …

A leishmaniose é uma doença que merece atenção, devido à grande variedade de
manifestações clínicas associadas e a sua elevada incidência anual. A pesquisa de novos …