Lamin dysfunction mediates neurodegeneration in tauopathies
B Frost, FH Bardai, MB Feany - Current Biology, 2016 - cell.com
The filamentous meshwork formed by the lamin nucleoskeleton provides a scaffold for the
anchoring of highly condensed heterochromatic DNA to the nuclear envelope, thereby …
anchoring of highly condensed heterochromatic DNA to the nuclear envelope, thereby …
Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models
SB Hannan, NM Dräger, TM Rasse… - Journal of …, 2016 - Wiley Online Library
Abnormal tau accumulations were observed and documented in post‐mortem brains of
patients affected by Alzheimer's disease (AD) long before the identification of mutations in …
patients affected by Alzheimer's disease (AD) long before the identification of mutations in …
[图书][B] Understanding Pathophysiology of Sporadic Parkinson's Disease in Drosophila Model: Potential Opportunities and Notable Limitations
P Modi, A Mohamad, L Phom, Z Koza, A Das… - 2016 - books.google.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
approximately 1% of the population over age 50. PD is widely accepted as a multifactorial …
approximately 1% of the population over age 50. PD is widely accepted as a multifactorial …
Drosophila ataxin‐2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues
MCB Vianna, DC Poleto, PF Gomes, V Valente… - FEBS Open …, 2016 - Wiley Online Library
Different isoforms of ataxin‐2 are predicted in Drosophila and may underlie different cellular
processes. Here, we validated the isoforms B and C of Drosophila ataxin‐2 locus (dAtx2) …
processes. Here, we validated the isoforms B and C of Drosophila ataxin‐2 locus (dAtx2) …
Role of lysine deacetylases on transcription regulation and mitochondrial function in Huntington's disease
LC Naia - 2016 - search.proquest.com
Huntington's disease (HD) is a neurodegenerative disorder that gradually affects memory,
cognitive skills and normal movements of the affected individuals and for which no disease …
cognitive skills and normal movements of the affected individuals and for which no disease …