The bone marrow niche consists of stem and progenitor cells destined to become mature
cells such as haematopoietic elements, osteoblasts or adipocytes. Marrow cells, influenced …

The serine/threonine protein kinase, TBK1, plays a crucial role as the hub for many innate
immune signaling pathways that lead to the induction of type I interferon (IFN) and interferon …

Dissemination of cancer stem cells (CSCs) serves as the basis of metastasis. Recently, we
demonstrated that circulating prostate cancer targets the hematopoietic stem cell …

In tumor cells, the ability to maintain viability over long time periods without proliferation is
referred to as a state of dormancy. Maintenance of dormancy is controlled by numerous …

Prostate cancer (PCa) is known to develop resistance to chemotherapy. Growth arrest‐
specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers …

Disseminated tumor cells (DTCs) are detected early in the disease process in prostate
cancer (PCa) patients and can persist after radical prostatectomy. DTCs can remain dormant …

Histone deacetylase 6 is a multifunctional lysine deacetylase that is recently emerging as a
central facilitator of response to stress and may play an important role in cancer cell …

In this chapter, the contributions of cells in the immune system (monocyte-macrophages,
myeloid derived suppressor cells, mesenchymal stromal cells, T cell subsets, NK cells …