The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis
SD Prabhu, NG Frangogiannis - Circulation research, 2016 - Am Heart Assoc
In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …
Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)
NA Turner - Journal of molecular and cellular cardiology, 2016 - Elsevier
Cardiac fibroblasts (CF) are well-established as key regulators of extracellular matrix (ECM)
turnover in the context of myocardial remodelling and fibrosis. Recently, this cell type has …
turnover in the context of myocardial remodelling and fibrosis. Recently, this cell type has …
Reduced acute myocardial ischemia–reperfusion injury in IL-6-deficient mice employing a closed-chest model
WMC Jong, H Ten Cate, AC Linnenbank… - Inflammation …, 2016 - Springer
Objective and design We examined the role of IL-6 in the temporal development of cardiac
ischemia–reperfusion injury employing a closed-chest I/R model. Materials/methods …
ischemia–reperfusion injury employing a closed-chest I/R model. Materials/methods …
AMPK activation by metformin inhibits local innate immune responses in the isolated rat heart by suppression of TLR 4-related pathway
Toll like receptors (TLRs) are key players in the innate immune responses. The energy
sensing enzyme, AMPK, has been implicated in the modulation of immunity. The present …
sensing enzyme, AMPK, has been implicated in the modulation of immunity. The present …
胡黄连苦苷Ⅱ 在心肌缺血再灌注损伤中的保护作用及机制
张博方， 郭鑫， 陈静， 江洪 - 临床心血管病杂志, 2016 - cqvip.com
目的: 探讨胡黄连苦苷Ⅱ (picroside-Ⅱ, P-Ⅱ) 对心肌缺血再灌注(ischemia/reperfusion, I/R)
损伤的保护作用及其对TLR4/NF-κB 信号通路的影响. 方法: 30 只成年雄性SD 大鼠随机分为3 …
损伤的保护作用及其对TLR4/NF-κB 信号通路的影响. 方法: 30 只成年雄性SD 大鼠随机分为3 …
[引用][C] Loss of TLR4 in a murine model of left anterior descending myocardial infarction modifies early remodeling, but does not provide long-term benefit
S Cai, S Rohailla, J Peng… - International …, 2016 - internationaljournalofcardiology.com
Toll-like receptors (TLRs) play an important role in the innate immune system, which in turn
has been shown to be involved in both acute ischemia–reperfusion injury and chronic …
has been shown to be involved in both acute ischemia–reperfusion injury and chronic …