Bromodomains are epigenetic readers of histone acetylation involved in chromatin
remodeling and transcriptional regulation. The human proteome comprises 46 …

The bromodomains and extra-terminal domain (BET) family proteins recognize acetylated
chromatin through their bromodomains (BDs) and help in regulating gene expression. BDs …

The bromodomain containing proteins TRIM24 (tripartite motif containing protein 24) and
BRPF1 (bromodomain and PHD finger containing protein 1) are involved in the epigenetic …

Bromodomains are acetyl-lysine specific protein interaction domains that have recently
emerged as a new target class for the development of inhibitors that modulate gene …

The functionality of stem cells declines during ageing, and this decline contributes to ageing-
associated impairments in tissue regeneration and function. Alterations in developmental …

The bromodomain (BrD) is a conserved protein modular domain found in many chromatin-
and transcription-associated proteins that has the ability to recognize acetylated lysine …

Primary effusion lymphoma (PEL) is an aggressive type of non-Hodgkin lymphoma localized
predominantly in body cavities. Kaposi's sarcoma-associated herpes virus (KSHV) is the …

Bromodomains (BRDs) have emerged as compelling targets for cancer therapy. The
development of selective and potent BET (bromo and extra-terminal) inhibitors and their …

TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in
diverse tumors, and high expression levels have been linked to poor prognosis in breast …

The discovery of inhibitors of bromodomain and extra terminal domain (BET) has achieved
great progress, and at least seven inhibitors have progressed into clinical trials for the …