The NMDA receptor (R) participates in many important physiological and pathological
processes. For example, its activation is required for both long-term potentiation (LTP) and …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which
causes the deterioration of memory and other cognitive abilities of the elderly. Previous lines …

Soluble amyloid-beta (Aβ) aggregates likely contribute substantially to the dementia that
characterizes Alzheimer's disease. However, despite intensive study of in vitro preparations …

Mounting evidence indicates that impairments of synaptic efficacy and/or plasticity may be a
key step in the development of Alzheimer's disease (AD) pathophysiology. Among the 2 …

Introduction Alzheimer's disease (AD) is characterized by appearance of both extracellular
senile plaques and intracellular neurofibrillary tangles, comprised of aggregates of …

It is well accepted that cortical and hippocampal synaptic densities are reduced in
Alzheimer's disease (AD). These alterations in neuronal networking occur at the very onset …

Prions are composed of the misfolded prion protein (PrPSc) organized in a variety of
aggregates. An important question in the prion field has been to determine the identity of …

Small proteins like amyloid beta (Aβ) monomers are related to neurodegenerative disorders
by aggregation to insoluble fibrils. Small angle neutron scattering (SANS) is a …

Self-assembly of amyloid β-protein (Aβ) into neurotoxic oligomers and fibrillar aggregates is
a key process thought to be the proximal event leading to development of Alzheimer's …

Disruption of synaptic function at excitatory synapses is one of the earliest pathological
changes seen in wide range of neurological diseases. The proper control of the segregation …