Targeted therapies are substantially changing the management of lung cancers. These
treatments include drugs that target driver mutations, those that target presumed important …

Abstract Fibroblast growth factor (FGF) 2, FGF4, FGF7 and FGF20 are representative
paracrine FGFs binding to heparan-sulfate proteoglycan and fibroblast growth factor …

Purpose: Molecular profiling may have prognostic and predictive value, and is increasingly
used in the clinical setting. There are more than a dozen fibroblast growth factor receptor …

Lung cancer is a leading cause of cancer-related mortality worldwide, and is classically
divided into two major histological subtypes: non-small-cell lung cancer (NSCLC) and small …

Loss-of-function mutations in the CBP/CREBBP gene, which encodes a histone
acetyltransferase (HAT), are present in a variety of human tumors, including lung, bladder …

Dysregulation of Fibroblast Growth Factor Receptor (FGFR) signaling through amplifications,
mutations, and gene fusions has been implicated in a broad array of cancers (eg liver …

Lung squamous cell carcinoma (LSCC) is a devastating malignancy with no effective
treatments, due to its complex genomic profile. Therefore, preclinical models mimicking its …

Lung cancer remains the leading cause of cancer-related death worldwide. NSCLC
accounts for more than 85% of all lung cancers, and the prognosis for advanced-stage …

Fibroblast growth factors (FGFs) regulate a plethora of biological functions, in both the
embryonic and adult stages of development, binding their cognate receptors and thus …

Cigarette smoking has reached epidemic proportions within many regions of the world and
remains the highest risk factor for chronic obstructive pulmonary disease (COPD) and lung …