Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

Assembly of metagenomic sequence data into microbial genomes is of fundamental value to
improving our understanding of microbial ecology and metabolism by elucidating the …

Long-range and highly accurate de novo assembly from short-read data is one of the most
pressing challenges in genomics. Recently, it has been shown that read pairs generated by …

Many genomes display high levels of heterozygosity (ie presence of different alleles at the
same loci in homologous chromosomes), being those of hybrid organisms an extreme such …

As the cost of sequencing continues to decrease and the amount of sequence data
generated grows, new paradigms for data storage and analysis are increasingly important …

Genome assemblies that are accurate, complete and contiguous are essential for identifying
important structural and functional elements of genomes and for identifying genetic variation …

Despite half a century of research, the biology of dinoflagellates remains enigmatic: they
defy many functional and genetic traits attributed to typical eukaryotic cells. Genomic …

Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

As sequencing technologies become more affordable, it is now realistic to propose studying
the evolutionary history of virtually any organism on a genomic scale. However, when …

The generation of large-scale biomedical data is creating unprecedented opportunities for
basic and translational science. Typically, the data producers perform initial analyses, but it …