[HTML][HTML] The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications

P Economopoulou, C Perisanidis… - Annals of …, 2016 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, with low
survival rates for advanced stage tumors and minimal improvement in survival trends …

HPV positive head and neck cancers: molecular pathogenesis and evolving treatment strategies

R Dok, S Nuyts - Cancers, 2016 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that
is the result of tobacco and/or alcohol abuse or infection with high-risk Human …

Association of human papillomavirus and p16 status with outcomes in the IMCL-9815 phase III registration trial for patients with locoregionally advanced …

DI Rosenthal, PM Harari, J Giralt, D Bell… - Journal of Clinical …, 2016 - ascopubs.org
Purpose We conducted a retrospective evaluation of the IMCL-9815 study to examine the
association of human papillomavirus (HPV) and p16 protein expression status with …

Anti-EGFR targeted monoclonal antibody isotype influences antitumor cellular immunity in head and neck cancer patients

S Trivedi, RM Srivastava, F Concha-Benavente… - Clinical Cancer …, 2016 - AACR
Purpose: EGF receptor (EGFR) is highly overexpressed on several cancers and two targeted
anti-EGFR antibodies which differ by isotype are FDA-approved for clinical use. Cetuximab …

Molecular profiling of head and neck squamous cell carcinoma

R Feldman, Z Gatalica, J Knezetic, S Reddy… - Head & …, 2016 - Wiley Online Library
Background Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of
recurrence, and with few approved targeted agents, novel treatments are needed. We …

[HTML][HTML] Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell …

F Braig, M Voigtlaender, A Schieferdecker, CJ Busch… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a
substantial proportion of patients with head and neck squamous cell carcinoma - PMC Back to …

Recommendations for the prophylactic management of skin reactions induced by epidermal growth factor receptor inhibitors in patients with solid tumors

RD Hofheinz, G Deplanque, Y Komatsu… - The …, 2016 - academic.oup.com
Inhibition of the epidermal growth factor receptor (EGFR) is an established treatment that
extends patient survival across a variety of tumor types. EGFR inhibitors fall into two main …

Molecularly targeted therapy for the treatment of head and neck cancer: a review of the ErbB family inhibitors

AG Sacco, FP Worden - OncoTargets and therapy, 2016 - Taylor & Francis
The majority of patients with head and neck squamous cell carcinoma (HNSCC) present
with locally advanced disease, which requires site-specific combinations of surgery …

[HTML][HTML] Updated overview of current biomarkers in head and neck carcinoma

K Dahiya, R Dhankhar - World journal of methodology, 2016 - ncbi.nlm.nih.gov
Squamous cell cancer is the most common type of malignancy arising from the epithelial
cells of the head and neck region. Head and neck squamous cell carcinoma (HNSCC) is …

Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives

S Ausoni, P Boscolo-Rizzo, B Singh… - Cancer and Metastasis …, 2016 - Springer
Despite improvements in functional outcomes attributable to advances in radiotherapy,
chemotherapy, surgical techniques, and imaging techniques, survival in head and neck …