We present data from animal studies showing that the pedunculopontine tegmental nucleus—
conserved through evolution, compartmentalized, and with a complex pattern of inputs and …

Introduction Traditionally, deep brain stimulation (DBS) for movement disorders (MDs) is
provided using stimulation frequencies equal to or above 100 Hz. However, recent evidence …

Background STN-DBS is well established to improve motor symptoms and quality of life in
patients with PD. While non-motor symptoms are crucial for quality of life in these patients …

Background: Pedunculopontine nucleus (PPN) has complex reciprocal connections with
basal ganglia, especially with internal globus pallidus and substantia nigra, and it has been …

Recent discoveries on the nature of the activity generated by the reticular activating system
(RAS) suggest that arousal is much more involved in perception and movement than …

Parkinson's disease (PD) is a complex neurodegenerative disorder that is currently
managed using a broad array of symptom-based strategies. However, targeting its …

We previously reported a loss of cholinergic neurons within the pedunculopontine tegmental
nucleus (PPTg) in rats that had been intra-nigrally lesioned with the proteasomal inhibitor …

Sleep medicine encompasses an unusually board spectrum of contributions from biology,
technology, and medicine. This volume summarizes the considerable mass of knowledge …

The failure of conventional therapies to fully control symptoms of movement disorders or
neuropsychiatric conditions has led to renewed interest in functional neurosurgery for these …

Нарушения сна и бодрствования практически облигатные проявления болезни
Паркинсона (БП), которые оказывают негативное воздействие на повседневную …