Alzheimer's disease

P Scheltens, K Blennow, MMB Breteler, B De Strooper… - The Lancet, 2016 - thelancet.com
Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

2016 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2016 - Elsevier
This report describes the public health impact of Alzheimer's disease, including incidence
and prevalence, mortality rates, costs of care, and the overall impact on caregivers and …

Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria

B Dubois, H Hampel, HH Feldman, P Scheltens… - Alzheimer's & …, 2016 - Elsevier
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Impact of hypertension on cognitive function: a scientific statement from the American Heart Association

C Iadecola, K Yaffe, J Biller, LC Bratzke, FM Faraci… - …, 2016 - Am Heart Assoc
Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

[HTML][HTML] Drug treatments in Alzheimer's disease

R Briggs, SP Kennelly, D O'Neill - Clinical medicine, 2016 - Elsevier
Despite the significant public health issue that it poses, only five medical treatments have
been approved for Alzheimer's disease (AD) and these act to control symptoms rather than …

Cognitive reserve and the prevention of dementia: the role of physical and cognitive activities

ST Cheng - Current psychiatry reports, 2016 - Springer
Abstract Purpose of Review The article discusses the two most significant modifiable risk
factors for dementia, namely, physical inactivity and lack of stimulating cognitive activity, and …

Research priorities to reduce the global burden of dementia by 2025

H Shah, E Albanese, C Duggan, I Rudan… - The Lancet …, 2016 - thelancet.com
Summary At the First WHO Ministerial Conference on Global Action Against Dementia in
March, 2015, 160 delegates, including representatives from 80 WHO Member States and …

Cerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomography

S Palmqvist, N Mattsson, O Hansson… - Brain, 2016 - academic.oup.com
Abstract See Rabinovici (doi: 10.1093/brain/aww025) for a scientific commentary on this
article. Cerebral accumulation of amyloid-β is thought to be the starting mechanism in …

Can physical exercise in old age improve memory and hippocampal function?

E Duzel, H van Praag, M Sendtner - Brain, 2016 - academic.oup.com
Physical exercise can convey a protective effect against cognitive decline in ageing and
Alzheimer's disease. While the long-term health-promoting and protective effects of exercise …